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10.1080/21688370.2021.1937013

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suck abstract from ncbi


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pmid34232823      Tissue+Barriers 2021 ; 9 (4): 1937013
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  • The blood-gas barrier in COVID-19: an overview of the effects of SARS-CoV-2 infection on the alveolar epithelial and endothelial cells of the lung #MMPMID34232823
  • Shirvaliloo M
  • Tissue Barriers 2021[Oct]; 9 (4): 1937013 PMID34232823show ga
  • Blood-gas barrier (BGB) or alveolar-capillary barrier is the primary tissue barrier affected by coronavirus disease 2019 (COVID-19). Comprising alveolar epithelial cells (AECs), endothelial cells (ECs) and the extracellular matrix (ECM) in between, the BGB is damaged following the action of multiple pro-inflammatory cytokines during acute inflammation. The infection of AECs and ECs with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen behind COVID-19, triggers an inflammatory response at the BGB, inducing the release of interleukin 1 (IL-1), IL-6, tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta), high mobility group box 1 (HMGB1), matrix metalloproteinases (MMPs), intercellular adhesion molecule-1 (ICAM-1) and platelet activating factor (PAF). The end result is the disassembly of adherens junctions (AJs) and tight junctions (TJs) in both AECs and ECs, AEC hyperplasia, EC pyroptosis, ECM remodeling and deposition of fibrin clots in the alveolar capillaries, leading to disintegration and thickening of the BGB, and ultimately, hypoxia. This commentary seeks to provide a brief account of how the BGB might become affected in COVID-19.
  • |*Pulmonary Gas Exchange[MESH]
  • |Alveolar Epithelial Cells/metabolism/pathology[MESH]
  • |Blood-Air Barrier/*metabolism/pathology[MESH]
  • |COVID-19/*metabolism/pathology[MESH]
  • |Humans[MESH]


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