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10.15252/emmm.202114167 http://scihub22266oqcxt.onion/10.15252/emmm.202114167 34232570!8687121!34232570     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Mol+Med 2021 ; 13 (8): e14167 Nephropedia Template TP {{tp|p=34232570|t=2021. High-resolution serum proteome trajectories in COVID-19 reveal patient-specific seroconversion |pdf=|usr=}}{{34232570}} gab.com Text High-resolution serum proteome trajectories in COVID-19 reveal patient-specific seroconversion JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=34232570 #FOAvip A deeper understanding of COVID-19 on human molecular pathophysiology is urgently needed as a foundation for the discovery of new biomarkers and therapeutic targets. Here we applied mass spectrometry (MS)-based proteomics to measure serum proteomes of COVID-19 patients and symptomatic, but PCR-negative controls, in a time-resolved manner. In 262 controls and 458 longitudinal samples of 31 patients, hospitalized for COVID-19, a remarkable 26% of proteins changed significantly. Bioinformatics analyses revealed co-regulated groups and shared biological functions. Proteins of the innate immune system such as CRP, SAA1, CD14, LBP, and LGALS3BP decreased early in the time course. Regulators of coagulation (APOH, FN1, HRG, KNG1, PLG) and lipid homeostasis (APOA1, APOC1, APOC2, APOC3, PON1) increased over the course of the disease. A global correlation map provides a system-wide functional association between proteins, biological processes, and clinical chemistry parameters. Importantly, five SARS-CoV-2 immunoassays against antibodies revealed excellent correlations with an extensive range of immunoglobulin regions, which were quantified by MS-based proteomics. The high-resolution profile of all immunoglobulin regions showed individual-specific differences and commonalities of potential pathophysiological relevance. Twit Text FOAVip High-resolution serum proteome trajectories in COVID-19 reveal patient-specific seroconversion ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=34232570 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34232570 #FOAvip English Wikipedia <ref>{{Cite pmid|34232570}}</ref> High-resolution serum proteome trajectories in COVID-19 reveal patient-specific seroconversion #MMPMID34232570 Geyer PE; Arend FM; Doll S; Louiset ML; Virreira Winter S; Muller-Reif JB; Torun FM; Weigand M; Eichhorn P; Bruegel M; Strauss MT; Holdt LM; Mann M; Teupser D EMBO Mol Med 2021[Aug]; 13 (8): e14167 PMID34232570show ga A deeper understanding of COVID-19 on human molecular pathophysiology is urgently needed as a foundation for the discovery of new biomarkers and therapeutic targets. Here we applied mass spectrometry (MS)-based proteomics to measure serum proteomes of COVID-19 patients and symptomatic, but PCR-negative controls, in a time-resolved manner. In 262 controls and 458 longitudinal samples of 31 patients, hospitalized for COVID-19, a remarkable 26% of proteins changed significantly. Bioinformatics analyses revealed co-regulated groups and shared biological functions. Proteins of the innate immune system such as CRP, SAA1, CD14, LBP, and LGALS3BP decreased early in the time course. Regulators of coagulation (APOH, FN1, HRG, KNG1, PLG) and lipid homeostasis (APOA1, APOC1, APOC2, APOC3, PON1) increased over the course of the disease. A global correlation map provides a system-wide functional association between proteins, biological processes, and clinical chemistry parameters. Importantly, five SARS-CoV-2 immunoassays against antibodies revealed excellent correlations with an extensive range of immunoglobulin regions, which were quantified by MS-based proteomics. The high-resolution profile of all immunoglobulin regions showed individual-specific differences and commonalities of potential pathophysiological relevance. |*COVID-19[MESH] |*Proteome[MESH] |Antibodies, Viral[MESH] |Aryldialkylphosphatase[MESH] |Humans[MESH] |Proteomics[MESH] |SARS-CoV-2[MESH]High-resolution serum proteome trajectories in COVID-19 reveal patient(epmc).pdf DeepDyve Pubget Overpricing