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10.1152/ajplung.00231.2021 http://scihub22266oqcxt.onion/10.1152/ajplung.00231.2021 34231390!8384475!34231390     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Lung+Cell+Mol+Physiol 2021 ; 321 (2): L485-L489 Nephropedia Template TP {{tp|p=34231390|t=2021. Erythrocytes identify complement activation in patients with COVID-19 |pdf=|usr=}}{{34231390}} gab.com Text Erythrocytes identify complement activation in patients with COVID-19 JO: Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=34231390 #FOAvip COVID-19, the disease caused by the SARS-CoV-2 virus, can progress to multisystem organ failure and viral sepsis characterized by respiratory failure, arrhythmias, thromboembolic complications, and shock with high mortality. Autopsy and preclinical evidence implicate aberrant complement activation in endothelial injury and organ failure. Erythrocytes express complement receptors and are capable of binding immune complexes; therefore, we investigated complement activation in patients with COVID-19 using erythrocytes as a tool to diagnose complement activation. We discovered enhanced C3b and C4d deposition on erythrocytes in COVID-19 sepsis patients and non-COVID sepsis patients compared with healthy controls, supporting the role of complement in sepsis-associated organ injury. Our data suggest that erythrocytes may contribute to a precision medicine approach to sepsis and have diagnostic value in monitoring complement dysregulation in COVID-19-sepsis and non-COVID sepsis and identifying patients who may benefit from complement targeted therapies. Twit Text FOAVip Erythrocytes identify complement activation in patients with COVID-19 ????Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=34231390 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34231390 #FOAvip English Wikipedia <ref>{{Cite pmid|34231390}}</ref> Erythrocytes identify complement activation in patients with COVID-19 #MMPMID34231390 Lam LKM; Reilly JP; Rux AH; Murphy SJ; Kuri-Cervantes L; Weisman AR; Ittner CAG; Pampena MB; Betts MR; Wherry EJ; Song WC; Lambris JD; Meyer NJ; Cines DB; Mangalmurti NS Am J Physiol Lung Cell Mol Physiol 2021[Aug]; 321 (2): L485-L489 PMID34231390show ga COVID-19, the disease caused by the SARS-CoV-2 virus, can progress to multisystem organ failure and viral sepsis characterized by respiratory failure, arrhythmias, thromboembolic complications, and shock with high mortality. Autopsy and preclinical evidence implicate aberrant complement activation in endothelial injury and organ failure. Erythrocytes express complement receptors and are capable of binding immune complexes; therefore, we investigated complement activation in patients with COVID-19 using erythrocytes as a tool to diagnose complement activation. We discovered enhanced C3b and C4d deposition on erythrocytes in COVID-19 sepsis patients and non-COVID sepsis patients compared with healthy controls, supporting the role of complement in sepsis-associated organ injury. Our data suggest that erythrocytes may contribute to a precision medicine approach to sepsis and have diagnostic value in monitoring complement dysregulation in COVID-19-sepsis and non-COVID sepsis and identifying patients who may benefit from complement targeted therapies. |COVID-19/*complications/immunology/virology[MESH] |Complement Activation/*immunology[MESH] |Complement C3b/*immunology/metabolism[MESH] |Complement C4b/*immunology/metabolism[MESH] |Erythrocytes/*immunology/metabolism/virology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Peptide Fragments/*immunology/metabolism[MESH] |Respiratory Insufficiency/*diagnosis/immunology/metabolism/virology[MESH] |SARS-CoV-2/isolation & purification[MESH]Erythrocytes identify complement activation in patients with COVID-19 (epmc).pdf DeepDyve Pubget Overpricing