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10.23812/21-163-A http://scihub22266oqcxt.onion/10.23812/21-163-A 34231353!ä!34231353 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Regul+Homeost+Agents 2021 ; 35 (3): 881-887 Nephropedia Template TP {{tp|p=34231353|t=2021. Sensitivity of serology assay in Covid-19 diagnosis: does the antigen matter?|pdf=|usr=}}{{34231353}} gab.com Text Sensitivity of serology assay in Covid-19 diagnosis: does the antigen matter JO: J Biol Regul Homeost Agents http://www.kidney.de/pget.php?&tw=1&pmid=34231353 #FOAvip Since the spreading of Sar-CoV-2 in March 2020, many serologic tests have been developed to identify antibody responses. Indeed, different commercial kits are directed against different antigens and could utilise different methods thereby triggering confusion and criticism. Here, we compared two Food and Drug Administration (FDA)-approved automatized assays that detect IgG responses against spike or nucleocapsid protein of Sars-Cov-2 virus in 127 subjects among healthcare workers of IRCCS Policlinico San Donato (MI), Italy. We observed different kinetics of IgG responses, demonstrating the importance of timing of sampling to correctly interpret the results both for infection diagnosis and for epidemiologic studies. We observed that Anti-N response starts earlier than Anti-S1/S2 response but also decreases earlier, affecting the sensitivity of the tests at different time points. Combining two different assays, designed against different antigens, could reduce false negative results. Finally, we observed a patient who produced anti-nucleocapsid IgG, but not anti-spike IgG. In conclusion, we investigated antibody responses in Covid-19 disease, aiming to direct clinicians and laboratory scientists to correctly interpret serologic results by always paying attention to clinical history correlation, timing of sampling, methods and antigens used, to avoid false negative results and obtain relevant epidemiologic data. Twit Text FOAVip Sensitivity of serology assay in Covid-19 diagnosis: does the antigen matter ????J Biol Regul Homeost Agents http://www.kidney.de/pget.php?&tw=1&pmid=34231353 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34231353 #FOAvip English Wikipedia <ref>{{Cite pmid|34231353}}</ref> Sensitivity of serology assay in Covid-19 diagnosis: does the antigen matter? #MMPMID34231353 Sitzia C; Pistelli L; Cardani R; Renna LV; Ranucci M; Carrara M; Borlini S; Clerici P; Rampoldi B; Cornetta M; Corsi-Romanelli M J Biol Regul Homeost Agents 2021[May]; 35 (3): 881-887 PMID34231353show ga Since the spreading of Sar-CoV-2 in March 2020, many serologic tests have been developed to identify antibody responses. Indeed, different commercial kits are directed against different antigens and could utilise different methods thereby triggering confusion and criticism. Here, we compared two Food and Drug Administration (FDA)-approved automatized assays that detect IgG responses against spike or nucleocapsid protein of Sars-Cov-2 virus in 127 subjects among healthcare workers of IRCCS Policlinico San Donato (MI), Italy. We observed different kinetics of IgG responses, demonstrating the importance of timing of sampling to correctly interpret the results both for infection diagnosis and for epidemiologic studies. We observed that Anti-N response starts earlier than Anti-S1/S2 response but also decreases earlier, affecting the sensitivity of the tests at different time points. Combining two different assays, designed against different antigens, could reduce false negative results. Finally, we observed a patient who produced anti-nucleocapsid IgG, but not anti-spike IgG. In conclusion, we investigated antibody responses in Covid-19 disease, aiming to direct clinicians and laboratory scientists to correctly interpret serologic results by always paying attention to clinical history correlation, timing of sampling, methods and antigens used, to avoid false negative results and obtain relevant epidemiologic data. |*COVID-19[MESH] |Antibodies, Viral[MESH] |Humans[MESH] |Immunoglobulin G[MESH] |Italy[MESH] |SARS-CoV-2[MESH] |Sensitivity and Specificity[MESH] |Spike Glycoprotein, Coronavirus[MESH]Sensitivity of serology assay in Covid-19 diagnosis: does the antigen (epmc).pdf DeepDyve Pubget Overpricing