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10.1007/s00066-021-01803-3

http://scihub22266oqcxt.onion/10.1007/s00066-021-01803-3
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34230996!8260020!34230996
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suck abstract from ncbi


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pmid34230996      Strahlenther+Onkol 2021 ; 197 (11): 1010-1020
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  • Could pulmonary low-dose radiation therapy be an alternative treatment for patients with COVID-19 pneumonia? Preliminary results of a multicenter SEOR-GICOR nonrandomized prospective trial (IPACOVID trial) #MMPMID34230996
  • Arenas M; Algara M; De Febrer G; Rubio C; Sanz X; de la Casa MA; Vasco C; Marin J; Fernandez-Leton P; Villar J; Torres-Royo L; Villares P; Membrive I; Acosta J; Lopez-Cano M; Araguas P; Quera J; Rodriguez-Tomas F; Montero A
  • Strahlenther Onkol 2021[Nov]; 197 (11): 1010-1020 PMID34230996show ga
  • PURPOSE: To evaluate the efficacy and safety of lung low-dose radiation therapy (LD-RT) for pneumonia in patients with coronavirus disease 2019 (COVID-19). MATERIALS AND METHODS: Inclusion criteria comprised patients with COVID-19-related moderate-severe pneumonia warranting hospitalization with supplemental O(2) and not candidates for admission to the intensive care unit because of comorbidities or general status. All patients received single lung dose of 0.5?Gy. Respiratory and systemic inflammatory parameters were evaluated before irradiation, at 24?h and 1 week after LD-RT. Primary endpoint was increased in the ratio of arterial oxygen partial pressure (PaO(2)) or the pulse oximetry saturation (SpO(2)) to fractional inspired oxygen (FiO(2)) ratio of at least 20% at 24?h with respect to the preirradiation value. RESULTS: Between June and November 2020, 36 patients with COVID-19 pneumonia and a mean age of 84 years were enrolled. Seventeen were women and 19 were men and all of them had comorbidities. All patients had bilateral pulmonary infiltrates on chest X?ray. All patients received dexamethasone treatment. Mean SpO(2) pretreatment value was 94.28% and the SpO(2)/FiO(2) ratio varied from 255?mm Hg to 283?mm Hg at 24?h and to 381?mm Hg at 1 week, respectively. In those who survived (23/36, 64%), a significant improvement was observed in the percentage of lung involvement in the CT scan at 1 week after LD-RT. No adverse effects related to radiation treatment have been reported. CONCLUSIONS: LD-RT appears to be a feasible and safe option in a population with COVID-19 bilateral interstitial pneumonia in the presence of significant comorbidities.
  • |*SARS-CoV-2[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Anti-Inflammatory Agents/therapeutic use[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19/diagnostic imaging/mortality/*radiotherapy/therapy[MESH]
  • |Cause of Death[MESH]
  • |Combined Modality Therapy[MESH]
  • |Comorbidity[MESH]
  • |Dexamethasone/therapeutic use[MESH]
  • |Female[MESH]
  • |Ferritins/blood[MESH]
  • |Fibrin Fibrinogen Degradation Products/analysis[MESH]
  • |Hospital Mortality[MESH]
  • |Humans[MESH]
  • |Interleukin-6/blood[MESH]
  • |L-Lactate Dehydrogenase/blood[MESH]
  • |Lung Diseases, Interstitial/diagnostic imaging/drug therapy/radiotherapy/therapy[MESH]
  • |Lung/diagnostic imaging/radiation effects[MESH]
  • |Male[MESH]
  • |Oxygen Inhalation Therapy[MESH]
  • |Oxygen/blood/therapeutic use[MESH]
  • |Partial Pressure[MESH]
  • |Prospective Studies[MESH]
  • |Radiotherapy Dosage[MESH]
  • |Radiotherapy, Conformal/*methods[MESH]
  • |Severity of Illness Index[MESH]
  • |Tomography, X-Ray Computed[MESH]


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