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10.1038/s41467-021-24265-8

http://scihub22266oqcxt.onion/10.1038/s41467-021-24265-8
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34230477!8260641!34230477
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suck abstract from ncbi


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pmid34230477      Nat+Commun 2021 ; 12 (1): 4015
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  • Lack of consideration of sex and gender in COVID-19 clinical studies #MMPMID34230477
  • Brady E; Nielsen MW; Andersen JP; Oertelt-Prigione S
  • Nat Commun 2021[Jul]; 12 (1): 4015 PMID34230477show ga
  • Sex and gender differences impact the incidence of SARS-CoV-2 infection and COVID-19 mortality. Furthermore, sex differences influence the frequency and severity of pharmacological side effects. A large number of clinical trials to develop new therapeutic approaches and vaccines for COVID-19 are ongoing. We investigated the inclusion of sex and/or gender in COVID-19 studies on ClinicalTrials.gov, collecting data for the period January 1, 2020 to January 26, 2021. Here, we show that of the 4,420 registered SARS-CoV-2/COVID-19 studies, 935 (21.2%) address sex/gender solely in the context of recruitment, 237 (5.4%) plan sex-matched or representative samples or emphasized sex/gender reporting, and only 178 (4%) explicitly report a plan to include sex/gender as an analytical variable. Just eight (17.8%) of the 45 COVID-19 related clinical trials published in scientific journals until December 15, 2020 report sex-disaggregated results or subgroup analyses.
  • |COVID-19/epidemiology/*therapy[MESH]
  • |Clinical Studies as Topic/*statistics & numerical data[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Patient Selection[MESH]
  • |SARS-CoV-2[MESH]


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