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10.1126/scisignal.abf8483 http://scihub22266oqcxt.onion/10.1126/scisignal.abf8483 34230210!8432948!34230210     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Signal 2021 ; 14 (690): ä Nephropedia Template TP {{tp|p=34230210|t=2021. Kynurenic acid may underlie sex-specific immune responses to COVID-19 |pdf=|usr=}}{{34230210}} gab.com Text Kynurenic acid may underlie sex-specific immune responses to COVID-19 JO: Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=34230210 #FOAvip Coronavirus disease 2019 (COVID-19) has poorer clinical outcomes in males than in females, and immune responses underlie these sex-related differences. Because immune responses are, in part, regulated by metabolites, we examined the serum metabolomes of COVID-19 patients. In male patients, kynurenic acid (KA) and a high KA-to-kynurenine (K) ratio (KA:K) positively correlated with age and with inflammatory cytokines and chemokines and negatively correlated with T cell responses. Males that clinically deteriorated had a higher KA:K than those that stabilized. KA inhibits glutamate release, and glutamate abundance was lower in patients that clinically deteriorated and correlated with immune responses. Analysis of data from the Genotype-Tissue Expression (GTEx) project revealed that the expression of the gene encoding the enzyme that produces KA, kynurenine aminotransferase, correlated with cytokine abundance and activation of immune responses in older males. This study reveals that KA has a sex-specific link to immune responses and clinical outcomes in COVID-19, suggesting a positive feedback between metabolites and immune responses in males. Twit Text FOAVip Kynurenic acid may underlie sex-specific immune responses to COVID-19 ????Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=34230210 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34230210 #FOAvip English Wikipedia <ref>{{Cite pmid|34230210}}</ref> Kynurenic acid may underlie sex-specific immune responses to COVID-19 #MMPMID34230210 Cai Y; Kim DJ; Takahashi T; Broadhurst DI; Yan H; Ma S; Rattray NJW; Casanovas-Massana A; Israelow B; Klein J; Lucas C; Mao T; Moore AJ; Muenker MC; Oh JE; Silva J; Wong P; Ko AI; Khan SA; Iwasaki A; Johnson CH Sci Signal 2021[Jul]; 14 (690): ä PMID34230210show ga Coronavirus disease 2019 (COVID-19) has poorer clinical outcomes in males than in females, and immune responses underlie these sex-related differences. Because immune responses are, in part, regulated by metabolites, we examined the serum metabolomes of COVID-19 patients. In male patients, kynurenic acid (KA) and a high KA-to-kynurenine (K) ratio (KA:K) positively correlated with age and with inflammatory cytokines and chemokines and negatively correlated with T cell responses. Males that clinically deteriorated had a higher KA:K than those that stabilized. KA inhibits glutamate release, and glutamate abundance was lower in patients that clinically deteriorated and correlated with immune responses. Analysis of data from the Genotype-Tissue Expression (GTEx) project revealed that the expression of the gene encoding the enzyme that produces KA, kynurenine aminotransferase, correlated with cytokine abundance and activation of immune responses in older males. This study reveals that KA has a sex-specific link to immune responses and clinical outcomes in COVID-19, suggesting a positive feedback between metabolites and immune responses in males. |*SARS-CoV-2[MESH] |Adult[MESH] |Aged[MESH] |COVID-19/blood/*immunology[MESH] |Case-Control Studies[MESH] |Cytokine Release Syndrome/blood/etiology/immunology[MESH] |Cytokines/blood/immunology[MESH] |Female[MESH] |Humans[MESH] |Kynurenic Acid/blood/*immunology[MESH] |Logistic Models[MESH] |Male[MESH] |Metabolic Networks and Pathways/immunology[MESH] |Metabolomics[MESH] |Middle Aged[MESH] |Multivariate Analysis[MESH] |Severity of Illness Index[MESH] |Sex Factors[MESH] |Signal Transduction/immunology[MESH]Kynurenic acid may underlie sex-specific immune responses to COVID-19 (epmc).pdf DeepDyve Pubget Overpricing