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10.1111/febs.16114 http://scihub22266oqcxt.onion/10.1111/febs.16114 34228902!8420455!34228902     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34228902.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       FEBS+J 2021 ; 288 (17): 5163-5178 Nephropedia Template TP {{tp|p=34228902|t=2021. Identification of a special cell type as a determinant of the kidney tropism of SARS-CoV-2 |pdf=|usr=}}{{34228902}} gab.com Text Identification of a special cell type as a determinant of the kidney tropism of SARS-CoV-2 JO: FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=34228902 #FOAvip The kidney tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been well-validated clinically and often leads to various forms of renal damage in coronavirus disease-2019 (COVID-19) patients. However, the underlying mechanisms and diagnostic approaches remain to be determined. We interrogated the expression of virus-related host factors in single-cell RNA sequencing (scRNA-seq) datasets of normal human kidneys and kidneys with pre-existing diseases and validated the results with urinary proteomics of COVID-19 patients and healthy individuals. We also assessed the effects of genetic variants on kidney susceptibility using expression quantitative trait loci (eQTLs) databases. We identified a subtype of tubular cells, which we named PT-3 cells, as being vulnerable to SARS-CoV-2 infections in the kidneys. PT-3 cells were enriched in viral entry factors and replication and assembly machinery but lacked antiviral restriction factors. Immunohistochemistry confirmed positive staining of PT-3 cell marker SCL36A2 on kidney sections from COVID-19 patients. Urinary proteomic analyses of COVID-19 patients revealed that markers of PT-3 cells were significantly increased, along with elevated viral receptor angiotensin-converting enzyme 2. We further found that the proportion of PT-3 cells increased in diabetic nephropathy but decreased in kidney allografts and lupus nephropathy, suggesting that kidney susceptibility varied among these diseases. We finally identified several eQTLs that regulate the expression of host factors in kidney cells. PT-3 cells may represent a key determinant for the kidney tropism of SARS-CoV-2, and detection of PT-3 cells may be used to assess the risk of renal infection during COVID-19. Twit Text FOAVip Identification of a special cell type as a determinant of the kidney tropism of SARS-CoV-2 ????FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=34228902 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34228902 #FOAvip English Wikipedia <ref>{{Cite pmid|34228902}}</ref> Identification of a special cell type as a determinant of the kidney tropism of SARS-CoV-2 #MMPMID34228902 Lin H; Ma X; Xiao F; Su H; Shi Y; Liu Y; Song L; Zhang Z; Zhang C; Peng H FEBS J 2021[Sep]; 288 (17): 5163-5178 PMID34228902show ga The kidney tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been well-validated clinically and often leads to various forms of renal damage in coronavirus disease-2019 (COVID-19) patients. However, the underlying mechanisms and diagnostic approaches remain to be determined. We interrogated the expression of virus-related host factors in single-cell RNA sequencing (scRNA-seq) datasets of normal human kidneys and kidneys with pre-existing diseases and validated the results with urinary proteomics of COVID-19 patients and healthy individuals. We also assessed the effects of genetic variants on kidney susceptibility using expression quantitative trait loci (eQTLs) databases. We identified a subtype of tubular cells, which we named PT-3 cells, as being vulnerable to SARS-CoV-2 infections in the kidneys. PT-3 cells were enriched in viral entry factors and replication and assembly machinery but lacked antiviral restriction factors. Immunohistochemistry confirmed positive staining of PT-3 cell marker SCL36A2 on kidney sections from COVID-19 patients. Urinary proteomic analyses of COVID-19 patients revealed that markers of PT-3 cells were significantly increased, along with elevated viral receptor angiotensin-converting enzyme 2. We further found that the proportion of PT-3 cells increased in diabetic nephropathy but decreased in kidney allografts and lupus nephropathy, suggesting that kidney susceptibility varied among these diseases. We finally identified several eQTLs that regulate the expression of host factors in kidney cells. PT-3 cells may represent a key determinant for the kidney tropism of SARS-CoV-2, and detection of PT-3 cells may be used to assess the risk of renal infection during COVID-19. |*Proteomics[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Antiviral Agents/pharmacology[MESH] |Base Sequence[MESH] |COVID-19/*genetics/pathology/virology[MESH] |Diabetic Nephropathies/*genetics/pathology/virology[MESH] |Gene Expression Regulation/genetics[MESH] |Host-Pathogen Interactions/genetics[MESH] |Humans[MESH] |Kidney/pathology/virology[MESH] |Quantitative Trait Loci/genetics[MESH] |Receptors, Virus/genetics[MESH] |SARS-CoV-2/*genetics/pathogenicity[MESH] |Single-Cell Analysis[MESH] |Tropism/genetics[MESH] |Virus Internalization[MESH]Identification of a special cell type as a determinant of the kidney t(epmc).pdf DeepDyve Pubget Overpricing