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10.26355/eurrev_202106_26151 http://scihub22266oqcxt.onion/10.26355/eurrev_202106_26151 34227076!ä!34227076 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+Rev+Med+Pharmacol+Sci 2021 ; 25 (12): 4405-4412 Nephropedia Template TP {{tp|p=34227076|t=2021. Evolving biothreat of variant SARS-CoV-2 - molecular properties, virulence and epidemiology |pdf=|usr=}}{{34227076}} gab.com Text Evolving biothreat of variant SARS-CoV-2 - molecular properties, virulence and epidemiology JO: Eur Rev Med Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34227076 #FOAvip SARS-CoV-2 are enveloped RNA viruses that belong to the family Coronaviridae of genus Beta coronavirus, responsible for the COVID-19 pandemic. The mutation rate is high among RNA viruses and in particular, coronavirus replication is error prone with an estimated mutation rate of 4x10-4 nucleotide substitutions per site per year. Variants of SARS-CoV-2 have been reported from various countries like United Kingdom, South Africa, Denmark, Brazil and India. These variants evolved due to mutations in spike gene of SARS-CoV-2. The most concerning variants are Variant of Concern (VOC) 202012/01 from United Kingdom and B.1.617 variant of India. Other variants include B.1.351 lineages, cluster 5/SARS-CoV-2 variant of Denmark, 501.V2 variant/SARS-CoV-2 variant of South Africa, lineage B.1.1.248/lineage P.1 of Brazil. Mutations in S protein may result in changes in the transmissibility and virulence of SARS-CoV-2. To date, alterations in virulence or pathogenicity have been reported among the variants from many parts of the globe. In our opinion, since the S protein is significantly altered, the suitability of existing vaccine specifically targeting the S protein of SARS-CoV-2 variants is a major concern. The mutations in SARS-CoV-2 are a continuous and evolving process that may result in the transformation of naive SARS-CoV-2 into totally new subsets of antigenically different SARS-CoV-2 viruses over a period of time. Twit Text FOAVip Evolving biothreat of variant SARS-CoV-2 - molecular properties, virulence and epidemiology ????Eur Rev Med Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34227076 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34227076 #FOAvip English Wikipedia <ref>{{Cite pmid|34227076}}</ref> Evolving biothreat of variant SARS-CoV-2 - molecular properties, virulence and epidemiology #MMPMID34227076 Kannan S; Shaik Syed Ali P; Sheeza A Eur Rev Med Pharmacol Sci 2021[Jun]; 25 (12): 4405-4412 PMID34227076show ga SARS-CoV-2 are enveloped RNA viruses that belong to the family Coronaviridae of genus Beta coronavirus, responsible for the COVID-19 pandemic. The mutation rate is high among RNA viruses and in particular, coronavirus replication is error prone with an estimated mutation rate of 4x10-4 nucleotide substitutions per site per year. Variants of SARS-CoV-2 have been reported from various countries like United Kingdom, South Africa, Denmark, Brazil and India. These variants evolved due to mutations in spike gene of SARS-CoV-2. The most concerning variants are Variant of Concern (VOC) 202012/01 from United Kingdom and B.1.617 variant of India. Other variants include B.1.351 lineages, cluster 5/SARS-CoV-2 variant of Denmark, 501.V2 variant/SARS-CoV-2 variant of South Africa, lineage B.1.1.248/lineage P.1 of Brazil. Mutations in S protein may result in changes in the transmissibility and virulence of SARS-CoV-2. To date, alterations in virulence or pathogenicity have been reported among the variants from many parts of the globe. In our opinion, since the S protein is significantly altered, the suitability of existing vaccine specifically targeting the S protein of SARS-CoV-2 variants is a major concern. The mutations in SARS-CoV-2 are a continuous and evolving process that may result in the transformation of naive SARS-CoV-2 into totally new subsets of antigenically different SARS-CoV-2 viruses over a period of time. |COVID-19/*epidemiology/*genetics/transmission[MESH] |Humans[MESH] |India/epidemiology[MESH] |Mutation/*genetics[MESH] |Protein Structure, Secondary[MESH] |SARS-CoV-2/chemistry/*genetics/*pathogenicity[MESH] |United Kingdom/epidemiology[MESH]Evolving biothreat of variant SARS-CoV-2 - molecular properties, virul(epmc).pdf DeepDyve Pubget Overpricing