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10.1038/s41467-021-24360-w http://scihub22266oqcxt.onion/10.1038/s41467-021-24360-w 34226537!8257697!34226537     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 4117 Nephropedia Template TP {{tp|p=34226537|t=2021. Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity |pdf=|usr=}}{{34226537}} gab.com Text Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34226537 #FOAvip Epidemiological and clinical reports indicate that SARS-CoV-2 virulence hinges upon the triggering of an aberrant host immune response, more so than on direct virus-induced cellular damage. To elucidate the immunopathology underlying COVID-19 severity, we perform cytokine and multiplex immune profiling in COVID-19 patients. We show that hypercytokinemia in COVID-19 differs from the interferon-gamma-driven cytokine storm in macrophage activation syndrome, and is more pronounced in critical versus mild-moderate COVID-19. Systems modelling of cytokine levels paired with deep-immune profiling shows that classical monocytes drive this hyper-inflammatory phenotype and that a reduction in T-lymphocytes correlates with disease severity, with CD8+ cells being disproportionately affected. Antigen presenting machinery expression is also reduced in critical disease. Furthermore, we report that neutrophils contribute to disease severity and local tissue damage by amplification of hypercytokinemia and the formation of neutrophil extracellular traps. Together our findings suggest a myeloid-driven immunopathology, in which hyperactivated neutrophils and an ineffective adaptive immune system act as mediators of COVID-19 disease severity. Twit Text FOAVip Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34226537 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34226537 #FOAvip English Wikipedia <ref>{{Cite pmid|34226537}}</ref> Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity #MMPMID34226537 Vanderbeke L; Van Mol P; Van Herck Y; De Smet F; Humblet-Baron S; Martinod K; Antoranz A; Arijs I; Boeckx B; Bosisio FM; Casaer M; Dauwe D; De Wever W; Dooms C; Dreesen E; Emmaneel A; Filtjens J; Gouwy M; Gunst J; Hermans G; Jansen S; Lagrou K; Liston A; Lorent N; Meersseman P; Mercier T; Neyts J; Odent J; Panovska D; Penttila PA; Pollet E; Proost P; Qian J; Quintelier K; Raes J; Rex S; Saeys Y; Sprooten J; Tejpar S; Testelmans D; Thevissen K; Van Buyten T; Vandenhaute J; Van Gassen S; Velasquez Pereira LC; Vos R; Weynand B; Wilmer A; Yserbyt J; Garg AD; Matthys P; Wouters C; Lambrechts D; Wauters E; Wauters J Nat Commun 2021[Jul]; 12 (1): 4117 PMID34226537show ga Epidemiological and clinical reports indicate that SARS-CoV-2 virulence hinges upon the triggering of an aberrant host immune response, more so than on direct virus-induced cellular damage. To elucidate the immunopathology underlying COVID-19 severity, we perform cytokine and multiplex immune profiling in COVID-19 patients. We show that hypercytokinemia in COVID-19 differs from the interferon-gamma-driven cytokine storm in macrophage activation syndrome, and is more pronounced in critical versus mild-moderate COVID-19. Systems modelling of cytokine levels paired with deep-immune profiling shows that classical monocytes drive this hyper-inflammatory phenotype and that a reduction in T-lymphocytes correlates with disease severity, with CD8+ cells being disproportionately affected. Antigen presenting machinery expression is also reduced in critical disease. Furthermore, we report that neutrophils contribute to disease severity and local tissue damage by amplification of hypercytokinemia and the formation of neutrophil extracellular traps. Together our findings suggest a myeloid-driven immunopathology, in which hyperactivated neutrophils and an ineffective adaptive immune system act as mediators of COVID-19 disease severity. |*Neutrophil Activation[MESH] |Aged[MESH] |Antigen-Presenting Cells/immunology[MESH] |COVID-19/blood/*complications/*immunology/virology[MESH] |Case-Control Studies[MESH] |Cytokine Release Syndrome/blood/*complications/pathology/virology[MESH] |Cytokines/blood[MESH] |Extracellular Traps/metabolism[MESH] |Female[MESH] |Histocompatibility Antigens Class II/metabolism[MESH] |Humans[MESH] |Immunophenotyping[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/*pathology[MESH] |SARS-CoV-2/physiology[MESH]Monocyte-driven atypical cytokine storm and aberrant neutrophil activa(epmc).pdf DeepDyve Pubget Overpricing