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10.1016/j.vaccine.2021.06.068 http://scihub22266oqcxt.onion/10.1016/j.vaccine.2021.06.068 34226102!8233963!34226102     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34226102&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Vaccine 2021 ; 39 (32): 4399-4403 Nephropedia Template TP {{tp|p=34226102|t=2021. Laser-facilitated epicutaneous immunization of mice with SARS-CoV-2 spike protein induces antibodies inhibiting spike/ACE2 binding |pdf=|usr=}}{{34226102}} gab.com Text Laser-facilitated epicutaneous immunization of mice with SARS-CoV-2 spike protein induces antibodies inhibiting spike/ACE2 binding JO: Vaccine http://www.kidney.de/pget.php?&tw=1&pmid=34226102 #FOAvip The skin represents an attractive target tissue for vaccination against respiratory viruses such as SARS-CoV-2. Laser-facilitated epicutaneous immunization (EPI) has been established as a novel technology to overcome the skin barrier, which combines efficient delivery via micropores with an inherent adjuvant effect due to the release of danger-associated molecular patterns. Here we delivered the S1 subunit of the Spike protein of SARS-CoV-2 to the skin of BALB/c mice via laser-generated micropores with or without CpG-ODN1826 or the B subunit of heat-labile enterotoxin of E.coli (LT-B). EPI induced serum IgG titers of 1:3200 that could be boosted 5 to 10-fold by co-administration of LT-B and CpG, respectively. Sera were able to inhibit binding of the spike protein to its receptor ACE2. Our data indicate that delivery of recombinant spike protein via the skin may represent an alternative route for vaccines against Covid-19. Twit Text FOAVip Laser-facilitated epicutaneous immunization of mice with SARS-CoV-2 spike protein induces antibodies inhibiting spike/ACE2 binding ????Vaccine http://www.kidney.de/pget.php?&tw=1&pmid=34226102 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34226102 #FOAvip English Wikipedia <ref>{{Cite pmid|34226102}}</ref> Laser-facilitated epicutaneous immunization of mice with SARS-CoV-2 spike protein induces antibodies inhibiting spike/ACE2 binding #MMPMID34226102 Scheiblhofer S; Drothler S; Braun W; Braun R; Boesch M; Weiss R Vaccine 2021[Jul]; 39 (32): 4399-4403 PMID34226102show ga The skin represents an attractive target tissue for vaccination against respiratory viruses such as SARS-CoV-2. Laser-facilitated epicutaneous immunization (EPI) has been established as a novel technology to overcome the skin barrier, which combines efficient delivery via micropores with an inherent adjuvant effect due to the release of danger-associated molecular patterns. Here we delivered the S1 subunit of the Spike protein of SARS-CoV-2 to the skin of BALB/c mice via laser-generated micropores with or without CpG-ODN1826 or the B subunit of heat-labile enterotoxin of E.coli (LT-B). EPI induced serum IgG titers of 1:3200 that could be boosted 5 to 10-fold by co-administration of LT-B and CpG, respectively. Sera were able to inhibit binding of the spike protein to its receptor ACE2. Our data indicate that delivery of recombinant spike protein via the skin may represent an alternative route for vaccines against Covid-19. |*COVID-19[MESH] |*Spike Glycoprotein, Coronavirus[MESH] |Animals[MESH] |Antibodies, Viral[MESH] |COVID-19 Vaccines[MESH] |Humans[MESH] |Immunization[MESH] |Lasers[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Peptidyl-Dipeptidase A[MESH] |Protein Binding[MESH] |SARS-CoV-2[MESH]Laser-facilitated epicutaneous immunization of mice with SARS-CoV-2 sp(epmc).pdf DeepDyve Pubget Overpricing