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10.1016/j.diagmicrobio.2021.115449

http://scihub22266oqcxt.onion/10.1016/j.diagmicrobio.2021.115449
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34224944!8178064!34224944
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suck abstract from ncbi


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pmid34224944      Diagn+Microbiol+Infect+Dis 2021 ; 101 (2): 115449
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  • Evaluation of 2 commercial anti-SARS-CoV-2 antibody assays in an immunocompetent and immunocompromised inpatient population with COVID-19 #MMPMID34224944
  • Harrington D; Azim T; Rosmarin C; Cutino-Moguel T; Hopkins M
  • Diagn Microbiol Infect Dis 2021[Oct]; 101 (2): 115449 PMID34224944show ga
  • INTRODUCTION: During the COVID-19 pandemic, widespread introduction of SARS-CoV-2 antibody testing was introduced without a full understanding of the assays performance or the antibody kinetics following infection with SARS-CoV-2. METHODS: We performed an evaluation of 2 anti-SARS-CoV-2 antibody assays with a more detailed look into the effect of immune status on antibody sensitivity. RESULTS: Both assays demonstrated 100% specificity. The overall sensitivity of the Roche was 92.1% at >/=14 days and 94.8% at >/=21 days, and the overall sensitivity of the Abbott was 94.4% at >/=14 days and 98.2% at >/=21 days. 7/41 (17%) of patients included in this cohort were immunocompromised. Seroconversion was seen less commonly in the immunocompromised (4/7 [57.1%] seroconverted) and after excluding these patients 100% sensitivity was seen in both assays at >/=21 days. DISCUSSION: Performance of both assays in the immunocompetent appeared excellent after 21 days postsymptom onset. Both assays are highly specific.
  • |*COVID-19 Serological Testing[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |COVID-19/diagnosis/*immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunocompromised Host[MESH]
  • |Kinetics[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2/*immunology/isolation & purification[MESH]
  • |Sensitivity and Specificity[MESH]


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