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10.1093/infdis/jiab355

http://scihub22266oqcxt.onion/10.1093/infdis/jiab355
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34223909!8344430!34223909
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suck abstract from ncbi


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pmid34223909      J+Infect+Dis 2021 ; 224 (7): 1109-1114
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  • Limited Neutralization of Authentic Severe Acute Respiratory Syndrome Coronavirus 2 Variants Carrying E484K In Vitro #MMPMID34223909
  • Widera M; Wilhelm A; Hoehl S; Pallas C; Kohmer N; Wolf T; Rabenau HF; Corman VM; Drosten C; Vehreschild MJGT; Goetsch U; Gottschalk R; Ciesek S
  • J Infect Dis 2021[Oct]; 224 (7): 1109-1114 PMID34223909show ga
  • Whether monoclonal antibodies are able to neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern has been investigated using pseudoviruses. In this study we show that bamlanivimab, casirivimab, and imdevimab efficiently neutralize authentic SARS-CoV-2, including variant B.1.1.7 (alpha), but variants B.1.351 (beta) and P.2 (zeta) were resistant against bamlanivimab and partially resistant to casirivimab. Whether antibodies are able to neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variantshas been investigated using pseudoviruses. We show that authentic SARS-CoV-2 carrying E484K were resistant against bamlanivimab and less susceptible to casirivimab, convalescent and vaccine-elicited sera.
  • |Amino Acid Substitution[MESH]
  • |Antibodies, Monoclonal, Humanized/immunology[MESH]
  • |Antibodies, Viral/immunology[MESH]
  • |COVID-19/immunology/*virology[MESH]
  • |Humans[MESH]
  • |Mutation, Missense[MESH]
  • |Neutralization Tests[MESH]


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