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10.1002/cti2.1308 http://scihub22266oqcxt.onion/10.1002/cti2.1308 34221402!8245277!34221402     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34221402&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Transl+Immunology 2021 ; 10 (7): e1308 Nephropedia Template TP {{tp|p=34221402|t=2021. No evidence that plasmablasts transdifferentiate into developing neutrophils in severe COVID-19 disease |pdf=|usr=}}{{34221402}} gab.com Text No evidence that plasmablasts transdifferentiate into developing neutrophils in severe COVID-19 disease JO: Clin Transl Immunology http://www.kidney.de/pget.php?&tw=1&pmid=34221402 #FOAvip OBJECTIVES: A recent single-cell RNA sequencing study by Wilk et al. suggested that plasmablasts can transdifferentiate into 'developing neutrophils' in patients with severe COVID-19 disease. We explore the evidence for this. METHODS: We downloaded the original data and code used by the authors in their study to replicate their findings and explore the possibility that regressing out variables may have led the authors to overfit their data. RESULTS: The lineage relationship between plasmablasts and developing neutrophils breaks down when key features are not regressed out, and the data are not overfitted during the analysis. CONCLUSION: Plasmablasts do not transdifferentiate into developing neutrophils. The single-cell RNA sequencing is a powerful technique for biological discovery and hypothesis generation. However, caution should be exercised in the bioinformatic analysis and interpretation of the data and findings cross-validated by orthogonal techniques. Twit Text FOAVip No evidence that plasmablasts transdifferentiate into developing neutrophils in severe COVID-19 disease ????Clin Transl Immunology http://www.kidney.de/pget.php?&tw=1&pmid=34221402 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34221402 #FOAvip English Wikipedia <ref>{{Cite pmid|34221402}}</ref> No evidence that plasmablasts transdifferentiate into developing neutrophils in severe COVID-19 disease #MMPMID34221402 Alquicira-Hernandez J; Powell JE; Phan TG Clin Transl Immunology 2021[]; 10 (7): e1308 PMID34221402show ga OBJECTIVES: A recent single-cell RNA sequencing study by Wilk et al. suggested that plasmablasts can transdifferentiate into 'developing neutrophils' in patients with severe COVID-19 disease. We explore the evidence for this. METHODS: We downloaded the original data and code used by the authors in their study to replicate their findings and explore the possibility that regressing out variables may have led the authors to overfit their data. RESULTS: The lineage relationship between plasmablasts and developing neutrophils breaks down when key features are not regressed out, and the data are not overfitted during the analysis. CONCLUSION: Plasmablasts do not transdifferentiate into developing neutrophils. The single-cell RNA sequencing is a powerful technique for biological discovery and hypothesis generation. However, caution should be exercised in the bioinformatic analysis and interpretation of the data and findings cross-validated by orthogonal techniques. äNo evidence that plasmablasts transdifferentiate into developing neutr(epmc).pdf DeepDyve Pubget Overpricing