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10.3389/fendo.2021.644055 http://scihub22266oqcxt.onion/10.3389/fendo.2021.644055 34220703!8242942!34220703     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34220703&cmd=llinks): Failed to open stream: HTTP request failed! 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Covid-19 and Growth Hormone/Insulin-Like Growth Factor 1: Study in Critically and Non-Critically Ill Patients |pdf=|usr=}}{{34220703}} gab.com Text Covid-19 and Growth Hormone/Insulin-Like Growth Factor 1: Study in Critically and Non-Critically Ill Patients JO: Front Endocrinol (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=34220703 #FOAvip OBJECTIVE: We aimed to measure insulin-like growth factor 1 (IGF1) and growth hormone (GH) in critically and non-critically ill patients with Covid-19 and assess them vis-a-vis clinical and laboratory parameters and prognostic tools. SUBJECTS AND METHODS: We included patients who were admitted to the wards or the ICU of the largest Covid-19 referral hospital in Greece; patients with non-Covid-19 pneumonia served as controls. Apart from the routine laboratory work-up for Covid-19 we measured GH and IGF1 (and calculated normalized IGF-1 values as standard deviation scores; SDS), after blood sampling upon admission to the wards or the ICU. RESULTS: We studied 209 critically and non-critically ill patients with Covid-19 and 39 control patients. Patients with Covid-19 who were ICU non-survivors were older and presented with a worse hematological/biochemical profile (including white blood cell count, troponin, glucose, aminotransferases and lactate dehydrogenase) compared to ICU survivors or Covid-19 survivors in the wards. Overall, IGF-1 SDS was higher in Covid-19 survivors compared to non-survivors (-0.96 +/- 1.89 vs -2.05 +/- 2.48, respectively, p=0.030). No significant differences were noted in GH between the groups. Nevertheless, in critically ill patients with Covid-19, the prognostic value of IGF-1 (raw data), IGF-1 (SDS) and GH for survival/non-survival was on a par with that of APACHE II and SOFA (with a marginal difference between GH and SOFA). CONCLUSION: In conclusion, our findings suggest that there might be an association between low IGF1 (and possibly GH) and poor outcome in patients with Covid-19. Twit Text FOAVip Covid-19 and Growth Hormone/Insulin-Like Growth Factor 1: Study in Critically and Non-Critically Ill Patients ????Front Endocrinol (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=34220703 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34220703 #FOAvip English Wikipedia <ref>{{Cite pmid|34220703}}</ref> Covid-19 and Growth Hormone/Insulin-Like Growth Factor 1: Study in Critically and Non-Critically Ill Patients #MMPMID34220703 Ilias I; Diamantopoulos A; Botoula E; Athanasiou N; Zacharis A; Tsipilis S; Jahaj E; Vassiliou AG; Vassiliadi DA; Kotanidou A; Tsagarakis S; Dimopoulou I Front Endocrinol (Lausanne) 2021[]; 12 (ä): 644055 PMID34220703show ga OBJECTIVE: We aimed to measure insulin-like growth factor 1 (IGF1) and growth hormone (GH) in critically and non-critically ill patients with Covid-19 and assess them vis-a-vis clinical and laboratory parameters and prognostic tools. SUBJECTS AND METHODS: We included patients who were admitted to the wards or the ICU of the largest Covid-19 referral hospital in Greece; patients with non-Covid-19 pneumonia served as controls. Apart from the routine laboratory work-up for Covid-19 we measured GH and IGF1 (and calculated normalized IGF-1 values as standard deviation scores; SDS), after blood sampling upon admission to the wards or the ICU. RESULTS: We studied 209 critically and non-critically ill patients with Covid-19 and 39 control patients. Patients with Covid-19 who were ICU non-survivors were older and presented with a worse hematological/biochemical profile (including white blood cell count, troponin, glucose, aminotransferases and lactate dehydrogenase) compared to ICU survivors or Covid-19 survivors in the wards. Overall, IGF-1 SDS was higher in Covid-19 survivors compared to non-survivors (-0.96 +/- 1.89 vs -2.05 +/- 2.48, respectively, p=0.030). No significant differences were noted in GH between the groups. Nevertheless, in critically ill patients with Covid-19, the prognostic value of IGF-1 (raw data), IGF-1 (SDS) and GH for survival/non-survival was on a par with that of APACHE II and SOFA (with a marginal difference between GH and SOFA). CONCLUSION: In conclusion, our findings suggest that there might be an association between low IGF1 (and possibly GH) and poor outcome in patients with Covid-19. |*Critical Illness/mortality[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/diagnosis/*metabolism/mortality/*pathology[MESH] |Case-Control Studies[MESH] |Female[MESH] |Greece/epidemiology[MESH] |Hospitalization/statistics & numerical data[MESH] |Human Growth Hormone/*metabolism[MESH] |Humans[MESH] |Insulin-Like Growth Factor I/*metabolism[MESH] |Intensive Care Units/statistics & numerical data[MESH] |Male[MESH] |Middle Aged[MESH] |Prognosis[MESH] |SARS-CoV-2/physiology[MESH] |Severity of Illness Index[MESH]Covid-19 and Growth Hormone/Insulin-Like Growth Factor 1: Study in Cri(epmc).pdf DeepDyve Pubget Overpricing