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10.3389/fphar.2021.695237 http://scihub22266oqcxt.onion/10.3389/fphar.2021.695237 34220520!8242167!34220520     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Pharmacol 2021 ; 12 (ä): 695237 Nephropedia Template TP {{tp|p=34220520|t=2021. The Role and Mechanism of Histone Deacetylases in Acute Kidney Injury |pdf=|usr=}}{{34220520}} gab.com Text The Role and Mechanism of Histone Deacetylases in Acute Kidney Injury JO: Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34220520 #FOAvip Acute kidney injury (AKI) is a common clinical complication with an incidence of up to 8-18% in hospitalized patients. AKI is also a complication of COVID-19 patients and is associated with an increased risk of death. In recent years, numerous studies have suggested that epigenetic regulation is critically involved in the pathophysiological process and prognosis of AKI. Histone acetylation, one of the epigenetic regulations, is negatively regulated by histone deacetylases (HDACs). Increasing evidence indicates that HDACs play an important role in the pathophysiological development of AKI by regulation of apoptosis, inflammation, oxidative stress, fibrosis, cell survival, autophagy, ATP production, and mitochondrial biogenesis (MB). In this review, we summarize and discuss the role and mechanism of HDACs in the pathogenesis of AKI. Twit Text FOAVip The Role and Mechanism of Histone Deacetylases in Acute Kidney Injury ????Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34220520 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34220520 #FOAvip English Wikipedia <ref>{{Cite pmid|34220520}}</ref> The Role and Mechanism of Histone Deacetylases in Acute Kidney Injury #MMPMID34220520 Zhou X; Chen H; Shi Y; Ma X; Zhuang S; Liu N Front Pharmacol 2021[]; 12 (ä): 695237 PMID34220520show ga Acute kidney injury (AKI) is a common clinical complication with an incidence of up to 8-18% in hospitalized patients. AKI is also a complication of COVID-19 patients and is associated with an increased risk of death. In recent years, numerous studies have suggested that epigenetic regulation is critically involved in the pathophysiological process and prognosis of AKI. Histone acetylation, one of the epigenetic regulations, is negatively regulated by histone deacetylases (HDACs). Increasing evidence indicates that HDACs play an important role in the pathophysiological development of AKI by regulation of apoptosis, inflammation, oxidative stress, fibrosis, cell survival, autophagy, ATP production, and mitochondrial biogenesis (MB). In this review, we summarize and discuss the role and mechanism of HDACs in the pathogenesis of AKI. äThe Role and Mechanism of Histone Deacetylases in Acute Kidney Injury (epmc).pdf DeepDyve Pubget Overpricing