Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3389/fphar.2021.669642 http://scihub22266oqcxt.onion/10.3389/fphar.2021.669642 34220507!8248548!34220507     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Pharmacol 2021 ; 12 (ä): 669642 Nephropedia Template TP {{tp|p=34220507|t=2021. Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting M(pro) and Ameliorates Pulmonary Inflammation |pdf=|usr=}}{{34220507}} gab.com Text Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting M(pro) and Ameliorates Pulmonary Inflammation JO: Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34220507 #FOAvip The coronavirus disease 2019 (COVID-19) has spread widely around the world and has seriously affected the human health of tens of millions of people. In view of lacking anti-virus drugs target to SARS-CoV-2, there is an urgent need to develop effective new drugs. In this study, we reported our discovery of SARS-CoV-2 M(pro) inhibitors. We selected 15 natural compounds, including 7 flavonoids, 3 coumarins, 2 terpenoids, one henolic, one aldehyde and one steroid compound for molecular docking and enzymatic screening. Myricetin were identified to have potent inhibit activity with IC(50) 3.684 +/- 0.076 muM in the enzyme assay. The binding pose of Myricetin with SARS-CoV-2 M(pro) was identified using molecular docking method. In the binding pocket of SARS-CoV-2 M(pro), the chromone ring of Myricetin interacts with His41 through pi-pi stacking, and the 3'-, 4'- and 7-hydroxyl of Myricetin interact with Phe140, Glu166and Asp187 through hydrogen bonds. Significantly, our results showed that Myricetin has potent effect on bleomycin-induced pulmonary inflammation by inhibiting the infiltration of inflammatory cells and the secretion of inflammatory cytokines IL-6, IL-1alpha, TNF-alpha and IFN-gamma. Overall, Myricetin may be a potential drug for anti-virus and symptomatic treatment of COVID-19. Twit Text FOAVip Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting M(pro) and Ameliorates Pulmonary Inflammation ????Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34220507 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34220507 #FOAvip English Wikipedia <ref>{{Cite pmid|34220507}}</ref> Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting M(pro) and Ameliorates Pulmonary Inflammation #MMPMID34220507 Xiao T; Cui M; Zheng C; Wang M; Sun R; Gao D; Bao J; Ren S; Yang B; Lin J; Li X; Li D; Yang C; Zhou H Front Pharmacol 2021[]; 12 (ä): 669642 PMID34220507show ga The coronavirus disease 2019 (COVID-19) has spread widely around the world and has seriously affected the human health of tens of millions of people. In view of lacking anti-virus drugs target to SARS-CoV-2, there is an urgent need to develop effective new drugs. In this study, we reported our discovery of SARS-CoV-2 M(pro) inhibitors. We selected 15 natural compounds, including 7 flavonoids, 3 coumarins, 2 terpenoids, one henolic, one aldehyde and one steroid compound for molecular docking and enzymatic screening. Myricetin were identified to have potent inhibit activity with IC(50) 3.684 +/- 0.076 muM in the enzyme assay. The binding pose of Myricetin with SARS-CoV-2 M(pro) was identified using molecular docking method. In the binding pocket of SARS-CoV-2 M(pro), the chromone ring of Myricetin interacts with His41 through pi-pi stacking, and the 3'-, 4'- and 7-hydroxyl of Myricetin interact with Phe140, Glu166and Asp187 through hydrogen bonds. Significantly, our results showed that Myricetin has potent effect on bleomycin-induced pulmonary inflammation by inhibiting the infiltration of inflammatory cells and the secretion of inflammatory cytokines IL-6, IL-1alpha, TNF-alpha and IFN-gamma. Overall, Myricetin may be a potential drug for anti-virus and symptomatic treatment of COVID-19. äMyricetin Inhibits SARS-CoV-2 Viral Replication by Targeting M(pro) an(epmc).pdf DeepDyve Pubget Overpricing