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Atlas der SARS-CoV-2-RNA-Protein-Interaktionen in infizierten Zellen #MMPMID34219983
Schmidt N; Munschauer M
Biospektrum (Heidelb) 2021[]; 27 (4): 376-379 PMID34219983show ga
Using RNA antisense purification and mass spectrometry, we identified more than 100 human proteins that directly and specifically bind SARS-CoV-2 RNA in infected cells. To gain insights into the functions of selected RNA interactors, we applied genetic perturbation and pharmacological inhibition experiments, and mapped the contact sites on the viral RNA. This led to the identification of host dependency factors and defense strategies, which can guide the design of novel therapeutics against SARS-CoV-2.