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10.1007/s12268-021-1595-3

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34219981!8233622!34219981
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suck abstract from ncbi


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pmid34219981      Biospektrum+(Heidelb) 2021 ; 27 (4): 368-371
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  • SARS-CoV-2 Nsp1: Ein kleines Protein blockiert die Immunantwort #MMPMID34219981
  • Sparrer K; Kirchhoff F
  • Biospektrum (Heidelb) 2021[]; 27 (4): 368-371 PMID34219981show ga
  • The Coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To facilitate its own replication and avoid immune control, SARS-CoV-2 manipulates its target cells. Our results revealed that the SARS-CoV-2 non-structural protein 1 (Nsp1) plays a key role in viral immune evasion. It blocks the mRNA tunnel of the cellular ribosome, resulting in a shutdown of translation and strong attenuation of the host's antiviral immune response.
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