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10.1111/jocs.15785

http://scihub22266oqcxt.onion/10.1111/jocs.15785
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34219277!8447331!34219277
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suck abstract from ncbi


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pmid34219277      J+Card+Surg 2021 ; 36 (11): 4256-4264
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  • Hemoadsorption for management of patients on veno-venous ECMO support for severe COVID-19 acute respiratory distress syndrome #MMPMID34219277
  • Geraci TC; Kon ZN; Moazami N; Chang SH; Carillo J; Chen S; Fargnoli A; Alimi M; Pass H; Galloway A; Smith DE
  • J Card Surg 2021[Nov]; 36 (11): 4256-4264 PMID34219277show ga
  • BACKGROUND AND AIM: Patients with severe coronavirus disease 2019 (COVID-19) develop a profound cytokine-mediated pro-inflammatory response. This study reports outcomes in 10 patients with COVID-19 supported on veno-venous extracorporeal membrane oxygenation (VV-ECMO) who were selected for the emergency use of a hemoadsorption column integrated in the ECMO circuit. MATERIALS AND METHODS: Pre and posttreatment, clinical data, and inflammatory markers were assessed to determine the safety and feasibility of using this system and to evaluate the clinical effect. RESULTS: During hemoadsorption, median levels of interleukin (IL)-2R, IL-6, and IL-10 decreased by 54%, 86%, and 64%, respectively. Reductions in other markers were observed for lactate dehydrogenase (-49%), ferritin (-46%), d-dimer (-7%), C-reactive protein (-55%), procalcitonin (-76%), and lactate (-44%). Vasoactive-inotrope scores decreased significantly over the treatment interval (-80%). The median hospital length of stay was 53 days (36-85) and at 90-days post cannulation, survival was 90% which was similar to a group of patients without the use of hemoadsorption. CONCLUSIONS: Addition of hemoadsorption to VV-ECMO in patients with severe COVID-19 is feasible and reduces measured cytokine levels. However, in this small series, the precise impact on the overall clinical course and survival benefit still remains unknown.
  • |*COVID-19[MESH]
  • |*Extracorporeal Membrane Oxygenation[MESH]
  • |*Respiratory Distress Syndrome/therapy[MESH]
  • |Catheterization[MESH]
  • |Humans[MESH]


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