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10.1515/jbcpp-2020-0495 http://scihub22266oqcxt.onion/10.1515/jbcpp-2020-0495 34218545!ä!34218545 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Basic+Clin+Physiol+Pharmacol 2021 ; 33 (1): 17-25 Nephropedia Template TP {{tp|p=34218545|t=2021. A new application of mTOR inhibitor drugs as potential therapeutic agents for COVID-19 |pdf=|usr=}}{{34218545}} gab.com Text A new application of mTOR inhibitor drugs as potential therapeutic agents for COVID-19 JO: J Basic Clin Physiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34218545 #FOAvip Since December 2019, the COVID-19 emerging pandemic caused by SARS-CoV-2 has resulted in one of the most important global health threats. Concerning the absence of an approved effective vaccine or drug for the treatment and outcome improvement of COVID-19 patients, and the role of SARS-CoV-2 in activation of mammalian target of rapamycin (mTOR) pathway, we decided to review the previous data regarding the therapeutic effect of mTOR inhibitor drugs in COVID-19 patients. We searched the scientific databases such as Web of Science, Embase, Medline (PubMed), Scopus, and Google Scholar using appropriate keywords to find suitable studies or suggestions until October 2020. The findings of the current study confirmed that mTOR inhibitor drugs through suggested mechanisms such as T cell adjustment, induction of autophagy without apoptosis, reduction of viral replication, restoration of the T-cell function, decrease cytokine storm, and moderation of the mTOR-PI3K-AKT pathway activation bring about a therapeutic impact in COVID-19 patients. Taken together, it is necessary to find a suitable therapy for the COVID-19 pandemic emerging. In this regard, we clarify that it is valuable to consider the therapeutic effect of mTOR inhibitor drugs and metformin by its mTOR inhibition property in the treatment of COVID-19 patients. Twit Text FOAVip A new application of mTOR inhibitor drugs as potential therapeutic agents for COVID-19 ????J Basic Clin Physiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34218545 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34218545 #FOAvip English Wikipedia <ref>{{Cite pmid|34218545}}</ref> A new application of mTOR inhibitor drugs as potential therapeutic agents for COVID-19 #MMPMID34218545 Mashayekhi-Sardoo H; Hosseinjani H J Basic Clin Physiol Pharmacol 2021[Jul]; 33 (1): 17-25 PMID34218545show ga Since December 2019, the COVID-19 emerging pandemic caused by SARS-CoV-2 has resulted in one of the most important global health threats. Concerning the absence of an approved effective vaccine or drug for the treatment and outcome improvement of COVID-19 patients, and the role of SARS-CoV-2 in activation of mammalian target of rapamycin (mTOR) pathway, we decided to review the previous data regarding the therapeutic effect of mTOR inhibitor drugs in COVID-19 patients. We searched the scientific databases such as Web of Science, Embase, Medline (PubMed), Scopus, and Google Scholar using appropriate keywords to find suitable studies or suggestions until October 2020. The findings of the current study confirmed that mTOR inhibitor drugs through suggested mechanisms such as T cell adjustment, induction of autophagy without apoptosis, reduction of viral replication, restoration of the T-cell function, decrease cytokine storm, and moderation of the mTOR-PI3K-AKT pathway activation bring about a therapeutic impact in COVID-19 patients. Taken together, it is necessary to find a suitable therapy for the COVID-19 pandemic emerging. In this regard, we clarify that it is valuable to consider the therapeutic effect of mTOR inhibitor drugs and metformin by its mTOR inhibition property in the treatment of COVID-19 patients. |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/*pharmacology[MESH] |Humans[MESH] |Pandemics[MESH] |SARS-CoV-2/drug effects[MESH]A new application of mTOR inhibitor drugs as potential therapeutic age(epmc).pdf DeepDyve Pubget Overpricing