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10.1002/psp4.12681

http://scihub22266oqcxt.onion/10.1002/psp4.12681
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34218521!8420371!34218521
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suck abstract from ncbi


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pmid34218521      CPT+Pharmacometrics+Syst+Pharmacol 2021 ; 10 (9): 973-982
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  • Anti-SARS-CoV-2 Repurposing Drug Database: Clinical Pharmacology Considerations #MMPMID34218521
  • Zhang X; Yang Y; Grimstein M; Liu G; Kitabi E; Fan J; Wang YH; Earp J; Weaver JL; Zhu H; Liu J; Reynolds KS; Huang SM; Wang Y
  • CPT Pharmacometrics Syst Pharmacol 2021[Sep]; 10 (9): 973-982 PMID34218521show ga
  • A critical step to evaluate the potential in vivo antiviral activity of a drug is to connect the in vivo exposure to its in vitro antiviral activity. The Anti-SARS-CoV-2 Repurposing Drug Database is a database that includes both in vitro anti-SARS-CoV-2 activity and in vivo pharmacokinetic data to facilitate the extrapolation from in vitro antiviral activity to potential in vivo antiviral activity for a large set of drugs/compounds. In addition to serving as a data source for in vitro anti-SARS-CoV-2 activity and in vivo pharmacokinetic information, the database is also a calculation tool that can be used to compare the in vitro antiviral activity with in vivo drug exposure to identify potential anti-SARS-CoV-2 drugs. Continuous development and expansion are feasible with the public availability of this database.
  • |*Databases, Pharmaceutical[MESH]
  • |Antiviral Agents/pharmacokinetics/*pharmacology[MESH]
  • |Drug Repositioning/methods[MESH]
  • |Humans[MESH]


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