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10.1007/s11739-020-02621-8

http://scihub22266oqcxt.onion/10.1007/s11739-020-02621-8
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suck abstract from ncbi


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pmid34218413      Intern+Emerg+Med 2021 ; 16 (5): 1231-1237
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  • Arterial and venous thrombosis in coronavirus 2019 disease (Covid-19): relationship with mortality #MMPMID34218413
  • Violi F; Ceccarelli G; Cangemi R; Cipollone F; D'Ardes D; Oliva A; Pirro M; Rocco M; Alessandri F; D'Ettorre G; Lichtner M; Pignatelli P; Ferro D; Ruberto F; Lip GYH; Pugliese F; Mastroianni CM
  • Intern Emerg Med 2021[Aug]; 16 (5): 1231-1237 PMID34218413show ga
  • BACKGROUND: Patients with coronavirus disease 2019 (Covid-19) may experience venous thrombosis while data regarding arterial thrombosis are sparse. METHODS: Prospective multicenter study in 5 hospitals including 373 patients with Covid-19-related pneumonia. Demographic data, laboratory findings including coagulation tests and comorbidities were reported. During the follow-up any arterial or venous thrombotic events and death were registered. RESULTS: Among 373 patients, 75 (20%) had a thrombotic event and 75 (20%) died. Thrombotic events included 41 venous thromboembolism and 34 arterial thrombosis. Age, cardiovascular disease, intensive care unit treatment, white blood cells, D-dimer, albumin and troponin blood levels were associated with thrombotic events. In a multivariable regression logistic model, intensive care unit treatment (Odds Ratio [OR]: 6.0; 95% Confidence Interval [CI] 2.8-12.6; p < 0.001); coronary artery disease (OR: 2.4; 95% CI 1.4-5.0; p = 0.022); and albumin levels (OR: 0.49; 95% CI 0.28-0.87; p = 0.014) were associated with ischemic events. Age, sex, chronic obstructive pulmonary disease, diabetes, heart failure, coronary heart disease, intensive care unit treatment, in-hospital thrombotic events, D-dimer, C-reactive protein, troponin, and albumin levels were associated with mortality. A multivariable Cox regression analysis showed that in-hospital thrombotic events (hazard ratio [HR]: 2.72; 95% CI 1.59-4.65; p < 0.001), age (HR: 1.035; 95% CI 1.014-1.057; p = 0.001), and albumin (HR: 0.447; 95% CI 0.277-0.723; p = 0.001) predicted morality. CONCLUSIONS: Covid-19 patients experience an equipollent rate of venous and arterial thrombotic events, that are associated with poor survival. Early identification and appropriate treatment of Covid-19 patients at risk of thrombosis may improve prognosis.
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19/*complications/epidemiology[MESH]
  • |Coronary Artery Disease/epidemiology/*etiology[MESH]
  • |Female[MESH]
  • |Fibrin Fibrinogen Degradation Products/analysis[MESH]
  • |Humans[MESH]
  • |Intensive Care Units/organization & administration/statistics & numerical data[MESH]
  • |Kaplan-Meier Estimate[MESH]
  • |Logistic Models[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Mortality/*trends[MESH]
  • |Odds Ratio[MESH]
  • |Proportional Hazards Models[MESH]
  • |Prospective Studies[MESH]


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