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10.1016/j.tracli.2021.06.007 http://scihub22266oqcxt.onion/10.1016/j.tracli.2021.06.007 34217815!8247188!34217815     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34217815&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Transfus+Clin+Biol 2022 ; 29 (1): 70-74 Nephropedia Template TP {{tp|p=34217815|t=2022. SARS-CoV-2 infection in patients with beta-thalassemia: The French experience |pdf=|usr=}}{{34217815}} gab.com Text SARS-CoV-2 infection in patients with beta-thalassemia: The French experience JO: Transfus Clin Biol http://www.kidney.de/pget.php?&tw=1&pmid=34217815 #FOAvip INTRODUCTION: Because of iron overload complications, thrombosis and infectious predisposition, patients with severe forms of thalassemia are likely to be at increased risk of COVID-19 complications. RESULTS: A national survey conducted during the year 2020 across the French reference centers for hemoglobinopathies identified 16 cases of COVID-19 confirmed by RT-PCR in beta-thalassemia patients. Their age ranged from 11 months to 60 years. 15 patients were transfusion-dependent and 6 were splenectomized. Concerning iron overload related complications, none had diabetes or cirrhosis and only one had experienced heart failure. All 4 pediatric patients were pauci-symptomatic during the viral episode. Three patients (41, 49 and 57 years old) developed COVID-19 pneumonia requiring oxygen therapy without the need for mechanical ventilation. Neutropenia (absolute neutrophils count <0.5 10 (9)/L) was observed in 2 patients receiving long-term treatment with hydroxycarbamide and deferiprone. No thrombosis event, organ failure or death occurred. All patients recovered. CONCLUSION: Severity of COVID-19 in this population of young and middle-aged patients appeared increased compared to the general population but remained mild to moderate as already described in the few series reported in the literature. Occurrence of adverse events related to chronic treatment administered in thalassemia disease may be favored by the infectious episode. Twit Text FOAVip SARS-CoV-2 infection in patients with beta-thalassemia: The French experience ????Transfus Clin Biol http://www.kidney.de/pget.php?&tw=1&pmid=34217815 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34217815 #FOAvip English Wikipedia <ref>{{Cite pmid|34217815}}</ref> SARS-CoV-2 infection in patients with beta-thalassemia: The French experience #MMPMID34217815 Jean-Mignard E; De Luna G; Pascal L; Agouti I; Thuret I Transfus Clin Biol 2022[Feb]; 29 (1): 70-74 PMID34217815show ga INTRODUCTION: Because of iron overload complications, thrombosis and infectious predisposition, patients with severe forms of thalassemia are likely to be at increased risk of COVID-19 complications. RESULTS: A national survey conducted during the year 2020 across the French reference centers for hemoglobinopathies identified 16 cases of COVID-19 confirmed by RT-PCR in beta-thalassemia patients. Their age ranged from 11 months to 60 years. 15 patients were transfusion-dependent and 6 were splenectomized. Concerning iron overload related complications, none had diabetes or cirrhosis and only one had experienced heart failure. All 4 pediatric patients were pauci-symptomatic during the viral episode. Three patients (41, 49 and 57 years old) developed COVID-19 pneumonia requiring oxygen therapy without the need for mechanical ventilation. Neutropenia (absolute neutrophils count <0.5 10 (9)/L) was observed in 2 patients receiving long-term treatment with hydroxycarbamide and deferiprone. No thrombosis event, organ failure or death occurred. All patients recovered. CONCLUSION: Severity of COVID-19 in this population of young and middle-aged patients appeared increased compared to the general population but remained mild to moderate as already described in the few series reported in the literature. Occurrence of adverse events related to chronic treatment administered in thalassemia disease may be favored by the infectious episode. |*COVID-19[MESH] |*Iron Overload/epidemiology/etiology[MESH] |*Thalassemia[MESH] |*beta-Thalassemia/complications/therapy[MESH] |Child[MESH] |Humans[MESH] |Infant[MESH] |Middle Aged[MESH]SARS-CoV-2 infection in patients with beta-thalassemia: The French exp(epmc).pdf DeepDyve Pubget Overpricing