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10.1016/j.diabres.2021.108936 http://scihub22266oqcxt.onion/10.1016/j.diabres.2021.108936 34217771!8247195!34217771     free     free     free       Diabetes+Res+Clin+Pract 2021 ; 178 (ä): 108936 Nephropedia Template TP {{tp|p=34217771|t=2021. Is diabetes mellitus a wrongdoer to COVID-19 severity?|pdf=|usr=}}{{34217771}} gab.com Text Is diabetes mellitus a wrongdoer to COVID-19 severity JO: Diabetes Res Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=34217771 #FOAvip The coronavirus disease 19 (COVID-19) has turned out to be a pandemic in short period of time due to the high transmissibility of its causative agent, severe acute respiratory syndrome coronavirus 2. Various reports have suggested the promising link between overexpression of angiotensin converting enzyme 2 (ACE2) and COVID-19 pathogenesis. The severity of COVID-19 pathophysiology is greatly depended on several comorbidities, like hypertension, diabetes mellitus (DM), respiratory and cardiovascular disease, out of which DM has emerged as a major risk factor. The current review focuses on the link among the expression of ACE2, use of ACE inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), and risk of COVID-19 pathogenesis in DM. The review also emphasizes on synergistic detrimental effect of DM and COVID-19 on the immune system in provoking uncontrolled cytokine storm which eventually leads to lethal consequences. Finally, several possible therapeutic strategies have been highlighted to reduce the excess of risk associated with COVID-19 in people with DM. Twit Text FOAVip Is diabetes mellitus a wrongdoer to COVID-19 severity ????Diabetes Res Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=34217771 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34217771 #FOAvip English Wikipedia <ref>{{Cite pmid|34217771}}</ref> Is diabetes mellitus a wrongdoer to COVID-19 severity? #MMPMID34217771 Sarkar S; Das D; Borsingh Wann S; Kalita J; Manna P Diabetes Res Clin Pract 2021[Aug]; 178 (ä): 108936 PMID34217771show ga The coronavirus disease 19 (COVID-19) has turned out to be a pandemic in short period of time due to the high transmissibility of its causative agent, severe acute respiratory syndrome coronavirus 2. Various reports have suggested the promising link between overexpression of angiotensin converting enzyme 2 (ACE2) and COVID-19 pathogenesis. The severity of COVID-19 pathophysiology is greatly depended on several comorbidities, like hypertension, diabetes mellitus (DM), respiratory and cardiovascular disease, out of which DM has emerged as a major risk factor. The current review focuses on the link among the expression of ACE2, use of ACE inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), and risk of COVID-19 pathogenesis in DM. The review also emphasizes on synergistic detrimental effect of DM and COVID-19 on the immune system in provoking uncontrolled cytokine storm which eventually leads to lethal consequences. Finally, several possible therapeutic strategies have been highlighted to reduce the excess of risk associated with COVID-19 in people with DM. |*COVID-19/complications[MESH] |*Diabetes Mellitus/pathology[MESH] |Angiotensin Receptor Antagonists/therapeutic use[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Angiotensin-Converting Enzyme Inhibitors/therapeutic use[MESH] |Cytokine Release Syndrome[MESH] |Diabetes Complications[MESH] |Humans[MESH] |Renin-Angiotensin System[MESH]Is diabetes mellitus a wrongdoer to COVID-19 severity?(epmc).pdf DeepDyve Pubget Overpricing