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10.1016/j.antiviral.2021.105127 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2021.105127 34217752!8247284!34217752     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antiviral+Res 2021 ; 193 (ä): 105127 Nephropedia Template TP {{tp|p=34217752|t=2021. Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues |pdf=|usr=}}{{34217752}} gab.com Text Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=34217752 #FOAvip In this study, a series of 10 quinoline analogues was evaluated for their in vitro antiviral activity against a panel of alpha- and beta-coronaviruses, including the severe acute respiratory syndrome coronaviruses 1 and 2 (SARS-CoV-1 and SARS-CoV-2), as well as the human coronaviruses (HCoV) 229E and OC43. Chloroquine and hydroxychloroquine were the most potent with antiviral EC(50) values in the range of 0.12-12 muM. Chloroquine displayed the most favorable selectivity index (i.e. ratio cytotoxic versus antiviral concentration), being 165 for HCoV-OC43 in HEL cells. Potent anti-coronavirus activity was also observed with amodiaquine, ferroquine and mefloquine, although this was associated with substantial cytotoxicity for mefloquine. Primaquine, quinidine, quinine and tafenoquine only blocked coronavirus replication at higher concentrations, while piperaquine completely lacked antiviral and cytotoxic effects. A time-of-addition experiment in HCoV-229E-infected HEL cells revealed that chloroquine interferes with viral entry at a post-attachment stage. Using confocal microscopy, no viral RNA synthesis could be detected upon treatment of SARS-CoV-2-infected cells with chloroquine. The inhibition of SARS-CoV-2 replication by chloroquine and hydroxychloroquine coincided with an inhibitory effect on the autophagy pathway as visualized by a dose-dependent increase in LC3-positive puncta. The latter effect was less pronounced or even absent with the other quinolines. In summary, we showed that several quinoline analogues, including chloroquine, hydroxychloroquine, amodiaquine, ferroquine and mefloquine, exhibit broad anti-coronavirus activity in vitro. Twit Text FOAVip Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=34217752 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34217752 #FOAvip English Wikipedia <ref>{{Cite pmid|34217752}}</ref> Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues #MMPMID34217752 Persoons L; Vanderlinden E; Vangeel L; Wang X; Do NDT; Foo SC; Leyssen P; Neyts J; Jochmans D; Schols D; De Jonghe S Antiviral Res 2021[Sep]; 193 (ä): 105127 PMID34217752show ga In this study, a series of 10 quinoline analogues was evaluated for their in vitro antiviral activity against a panel of alpha- and beta-coronaviruses, including the severe acute respiratory syndrome coronaviruses 1 and 2 (SARS-CoV-1 and SARS-CoV-2), as well as the human coronaviruses (HCoV) 229E and OC43. Chloroquine and hydroxychloroquine were the most potent with antiviral EC(50) values in the range of 0.12-12 muM. Chloroquine displayed the most favorable selectivity index (i.e. ratio cytotoxic versus antiviral concentration), being 165 for HCoV-OC43 in HEL cells. Potent anti-coronavirus activity was also observed with amodiaquine, ferroquine and mefloquine, although this was associated with substantial cytotoxicity for mefloquine. Primaquine, quinidine, quinine and tafenoquine only blocked coronavirus replication at higher concentrations, while piperaquine completely lacked antiviral and cytotoxic effects. A time-of-addition experiment in HCoV-229E-infected HEL cells revealed that chloroquine interferes with viral entry at a post-attachment stage. Using confocal microscopy, no viral RNA synthesis could be detected upon treatment of SARS-CoV-2-infected cells with chloroquine. The inhibition of SARS-CoV-2 replication by chloroquine and hydroxychloroquine coincided with an inhibitory effect on the autophagy pathway as visualized by a dose-dependent increase in LC3-positive puncta. The latter effect was less pronounced or even absent with the other quinolines. In summary, we showed that several quinoline analogues, including chloroquine, hydroxychloroquine, amodiaquine, ferroquine and mefloquine, exhibit broad anti-coronavirus activity in vitro. |Animals[MESH] |Antimalarials/*pharmacology[MESH] |Antiviral Agents/*pharmacology[MESH] |COVID-19 Drug Treatment[MESH] |Chlorocebus aethiops[MESH] |Chloroquine/pharmacology[MESH] |Coronavirus 229E, Human/drug effects[MESH] |Coronavirus Infections/*drug therapy[MESH] |Coronavirus OC43, Human/drug effects[MESH] |Coronavirus/*drug effects[MESH] |Humans[MESH] |Hydroxychloroquine/pharmacology[MESH] |Quinolines/*pharmacology[MESH] |SARS-CoV-2/drug effects[MESH] |Vero Cells[MESH] |Virus Internalization/drug effects[MESH]Broad spectrum anti-coronavirus activity of a series of anti-malaria q(epmc).pdf DeepDyve Pubget Overpricing