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10.1186/s12872-021-02137-9 http://scihub22266oqcxt.onion/10.1186/s12872-021-02137-9 34217220!8254437!34217220     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34217220&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       BMC+Cardiovasc+Disord 2021 ; 21 (1): 327 Nephropedia Template TP {{tp|p=34217220|t=2021. Pre-existing cardiovascular disease rather than cardiovascular risk factors drives mortality in COVID-19 |pdf=|usr=}}{{34217220}} gab.com Text Pre-existing cardiovascular disease rather than cardiovascular risk factors drives mortality in COVID-19 JO: BMC Cardiovasc Disord http://www.kidney.de/pget.php?&tw=1&pmid=34217220 #FOAvip BACKGROUND: The relative association between cardiovascular (CV) risk factors, such as diabetes and hypertension, established CV disease (CVD), and susceptibility to CV complications or mortality in COVID-19 remains unclear. METHODS: We conducted a cohort study of consecutive adults hospitalised for severe COVID-19 between 1st March and 30th June 2020. Pre-existing CVD, CV risk factors and associations with mortality and CV complications were ascertained. RESULTS: Among 1721 patients (median age 71 years, 57% male), 349 (20.3%) had pre-existing CVD (CVD), 888 (51.6%) had CV risk factors without CVD (RF-CVD), 484 (28.1%) had neither. Patients with CVD were older with a higher burden of non-CV comorbidities. During follow-up, 438 (25.5%) patients died: 37% with CVD, 25.7% with RF-CVD and 16.5% with neither. CVD was independently associated with in-hospital mortality among patients < 70 years of age (adjusted HR 2.43 [95% CI 1.16-5.07]), but not in those >/= 70 years (aHR 1.14 [95% CI 0.77-1.69]). RF-CVD were not independently associated with mortality in either age group (< 70 y aHR 1.21 [95% CI 0.72-2.01], >/= 70 y aHR 1.07 [95% CI 0.76-1.52]). Most CV complications occurred in patients with CVD (66%) versus RF-CVD (17%) or neither (11%; p < 0.001). 213 [12.4%] patients developed venous thromboembolism (VTE). CVD was not an independent predictor of VTE. CONCLUSIONS: In patients hospitalised with COVID-19, pre-existing established CVD appears to be a more important contributor to mortality than CV risk factors in the absence of CVD. CVD-related hazard may be mediated, in part, by new CV complications. Optimal care and vigilance for destabilised CVD are essential in this patient group. Trial registration n/a. Twit Text FOAVip Pre-existing cardiovascular disease rather than cardiovascular risk factors drives mortality in COVID-19 ????BMC Cardiovasc Disord http://www.kidney.de/pget.php?&tw=1&pmid=34217220 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34217220 #FOAvip English Wikipedia <ref>{{Cite pmid|34217220}}</ref> Pre-existing cardiovascular disease rather than cardiovascular risk factors drives mortality in COVID-19 #MMPMID34217220 O'Gallagher K; Shek A; Bean DM; Bendayan R; Papachristidis A; Teo JTH; Dobson RJB; Shah AM; Zakeri R BMC Cardiovasc Disord 2021[Jul]; 21 (1): 327 PMID34217220show ga BACKGROUND: The relative association between cardiovascular (CV) risk factors, such as diabetes and hypertension, established CV disease (CVD), and susceptibility to CV complications or mortality in COVID-19 remains unclear. METHODS: We conducted a cohort study of consecutive adults hospitalised for severe COVID-19 between 1st March and 30th June 2020. Pre-existing CVD, CV risk factors and associations with mortality and CV complications were ascertained. RESULTS: Among 1721 patients (median age 71 years, 57% male), 349 (20.3%) had pre-existing CVD (CVD), 888 (51.6%) had CV risk factors without CVD (RF-CVD), 484 (28.1%) had neither. Patients with CVD were older with a higher burden of non-CV comorbidities. During follow-up, 438 (25.5%) patients died: 37% with CVD, 25.7% with RF-CVD and 16.5% with neither. CVD was independently associated with in-hospital mortality among patients < 70 years of age (adjusted HR 2.43 [95% CI 1.16-5.07]), but not in those >/= 70 years (aHR 1.14 [95% CI 0.77-1.69]). RF-CVD were not independently associated with mortality in either age group (< 70 y aHR 1.21 [95% CI 0.72-2.01], >/= 70 y aHR 1.07 [95% CI 0.76-1.52]). Most CV complications occurred in patients with CVD (66%) versus RF-CVD (17%) or neither (11%; p < 0.001). 213 [12.4%] patients developed venous thromboembolism (VTE). CVD was not an independent predictor of VTE. CONCLUSIONS: In patients hospitalised with COVID-19, pre-existing established CVD appears to be a more important contributor to mortality than CV risk factors in the absence of CVD. CVD-related hazard may be mediated, in part, by new CV complications. Optimal care and vigilance for destabilised CVD are essential in this patient group. Trial registration n/a. |*COVID-19/mortality/physiopathology/therapy[MESH] |*Cardiovascular Diseases/complications/diagnosis/epidemiology[MESH] |*Hospital Mortality[MESH] |*Venous Thromboembolism/diagnosis/epidemiology/etiology[MESH] |Age Factors[MESH] |Aged[MESH] |Cohort Studies[MESH] |Diabetes Mellitus/*epidemiology[MESH] |Female[MESH] |Heart Disease Risk Factors[MESH] |Humans[MESH] |Hypertension/*epidemiology[MESH] |Male[MESH] |Mortality[MESH] |Outcome and Process Assessment, Health Care[MESH] |Risk Assessment/methods/statistics & numerical data[MESH] |SARS-CoV-2/isolation & purification[MESH]Pre-existing cardiovascular disease rather than cardiovascular risk fa(epmc).pdf DeepDyve Pubget Overpricing