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Natural killer cells and unconventional T cells in COVID-19 #MMPMID34217135
Bjorkstrom NK; Ponzetta A
Curr Opin Virol 2021[Aug]; 49 (ä): 176-182 PMID34217135show ga
NK cells and diverse populations of unconventional T cells, such as MAIT cells, gammadelta T cells, invariant NKT cells, and DNT(abeta) cells are important early effector lymphocytes. While some of these cells, such as NK cell and MAIT cells, have well-established roles in antiviral defense, the function of other populations remains more elusive. Here, we summarize and discuss current knowledge on NK cell and unconventional T cell responses to SARS-CoV-2 infection. Also covered is the role of these cells in the pathogenesis of severe COVID-19. Understanding the early, both systemic and local (lung), effector lymphocyte response in this novel disease will likely aid ongoing efforts to combat the pandemic.
|COVID-19/*immunology/pathology[MESH]
|Cytokines/immunology[MESH]
|Humans[MESH]
|Killer Cells, Natural/*immunology[MESH]
|Lung/immunology/pathology[MESH]
|Mucosal-Associated Invariant T Cells/immunology[MESH]