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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Transfus+Apher+Sci 2021 ; 60 (5): 103200 Nephropedia Template TP
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A case of psoriasis successfully treated by extracorporeal photopheresis during COVID-19 pandemic #MMPMID34215520
Esme P; Coban SN; Ugur B; Ayli M; Caliskan E
Transfus Apher Sci 2021[Oct]; 60 (5): 103200 PMID34215520show ga
Psoriasis is a chronic inflammatory skin disease that is characterized by well-demarcated erythematous plaques with a silver scale. Although many new and emerging therapeutic agents are often sufficient to control the disease, there is still a need for alternative treatment options in challenging cases. Extracorporeal photopheresis (ECP) has been applied to many T-cell-mediated diseases to restore immune homeostasis and treat psoriasis effectively. In this paper, we present a psoriasis patient who did not respond to methotrexate, narrowband ultraviolet B, or acitretin. Because of a diagnosis of non-Hodgkin lymphoma, the patient had contraindications for cyclosporine, fumaric acid esters, and biologics but achieved remission with a total of 12 sessions of ECP in two and a half months. Although exacerbation was recorded after polymerase chain reaction (PCR) confirmed coronavirus 2019 (COVID-19) disease infection at the end of the first month, scores from the psoriasis area severity index (PASI) and dermatological life quality index (DLQI) were regressed significantly within two and a half months. ECP seems to provide an effective and rapid response for psoriasis and should be considered for psoriasis patients who fail to respond or have contraindications to existing treatments.
|*Pandemics[MESH]
|*Photopheresis[MESH]
|*SARS-CoV-2[MESH]
|Acitretin/therapeutic use[MESH]
|COVID-19/*complications[MESH]
|Chemical and Drug Induced Liver Injury/etiology[MESH]