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10.1016/j.transci.2021.103200

http://scihub22266oqcxt.onion/10.1016/j.transci.2021.103200
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34215520!8234246!34215520
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suck abstract from ncbi


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pmid34215520      Transfus+Apher+Sci 2021 ; 60 (5): 103200
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  • A case of psoriasis successfully treated by extracorporeal photopheresis during COVID-19 pandemic #MMPMID34215520
  • Esme P; Coban SN; Ugur B; Ayli M; Caliskan E
  • Transfus Apher Sci 2021[Oct]; 60 (5): 103200 PMID34215520show ga
  • Psoriasis is a chronic inflammatory skin disease that is characterized by well-demarcated erythematous plaques with a silver scale. Although many new and emerging therapeutic agents are often sufficient to control the disease, there is still a need for alternative treatment options in challenging cases. Extracorporeal photopheresis (ECP) has been applied to many T-cell-mediated diseases to restore immune homeostasis and treat psoriasis effectively. In this paper, we present a psoriasis patient who did not respond to methotrexate, narrowband ultraviolet B, or acitretin. Because of a diagnosis of non-Hodgkin lymphoma, the patient had contraindications for cyclosporine, fumaric acid esters, and biologics but achieved remission with a total of 12 sessions of ECP in two and a half months. Although exacerbation was recorded after polymerase chain reaction (PCR) confirmed coronavirus 2019 (COVID-19) disease infection at the end of the first month, scores from the psoriasis area severity index (PASI) and dermatological life quality index (DLQI) were regressed significantly within two and a half months. ECP seems to provide an effective and rapid response for psoriasis and should be considered for psoriasis patients who fail to respond or have contraindications to existing treatments.
  • |*Pandemics[MESH]
  • |*Photopheresis[MESH]
  • |*SARS-CoV-2[MESH]
  • |Acitretin/therapeutic use[MESH]
  • |COVID-19/*complications[MESH]
  • |Chemical and Drug Induced Liver Injury/etiology[MESH]
  • |Combined Modality Therapy[MESH]
  • |Contraindications, Drug[MESH]
  • |Cyclosporine/adverse effects[MESH]
  • |Humans[MESH]
  • |Lymphoma, Non-Hodgkin/*complications[MESH]
  • |Male[MESH]
  • |Methotrexate/adverse effects/therapeutic use[MESH]
  • |Middle Aged[MESH]
  • |Nails/pathology[MESH]
  • |Psoriasis/complications/*drug therapy/pathology/radiotherapy[MESH]
  • |Quality of Life[MESH]
  • |Severity of Illness Index[MESH]


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