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10.1126/science.abi4506 http://scihub22266oqcxt.onion/10.1126/science.abi4506 34214046!8899822!34214046     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2021 ; 373 (6558): 991-998 Nephropedia Template TP {{tp|p=34214046|t=2021. Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice |pdf=|usr=}}{{34214046}} gab.com Text Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=34214046 #FOAvip The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 and SARS-CoV-2 in 2019 highlights the need to develop universal vaccination strategies against the broader Sarbecovirus subgenus. Using chimeric spike designs, we demonstrate protection against challenge from SARS-CoV, SARS-CoV-2, SARS-CoV-2 B.1.351, bat CoV (Bt-CoV) RsSHC014, and a heterologous Bt-CoV WIV-1 in vulnerable aged mice. Chimeric spike messenger RNAs (mRNAs) induced high levels of broadly protective neutralizing antibodies against high-risk Sarbecoviruses. By contrast, SARS-CoV-2 mRNA vaccination not only showed a marked reduction in neutralizing titers against heterologous Sarbecoviruses, but SARS-CoV and WIV-1 challenge in mice resulted in breakthrough infections. Chimeric spike mRNA vaccines efficiently neutralized D614G, mink cluster five, and the UK B.1.1.7 and South African B.1.351 variants of concern. Thus, multiplexed-chimeric spikes can prevent SARS-like zoonotic coronavirus infections with pandemic potential. Twit Text FOAVip Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice ????Science http://www.kidney.de/pget.php?&tw=1&pmid=34214046 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34214046 #FOAvip English Wikipedia <ref>{{Cite pmid|34214046}}</ref> Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice #MMPMID34214046 Martinez DR; Schafer A; Leist SR; De la Cruz G; West A; Atochina-Vasserman EN; Lindesmith LC; Pardi N; Parks R; Barr M; Li D; Yount B; Saunders KO; Weissman D; Haynes BF; Montgomery SA; Baric RS Science 2021[Aug]; 373 (6558): 991-998 PMID34214046show ga The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 and SARS-CoV-2 in 2019 highlights the need to develop universal vaccination strategies against the broader Sarbecovirus subgenus. Using chimeric spike designs, we demonstrate protection against challenge from SARS-CoV, SARS-CoV-2, SARS-CoV-2 B.1.351, bat CoV (Bt-CoV) RsSHC014, and a heterologous Bt-CoV WIV-1 in vulnerable aged mice. Chimeric spike messenger RNAs (mRNAs) induced high levels of broadly protective neutralizing antibodies against high-risk Sarbecoviruses. By contrast, SARS-CoV-2 mRNA vaccination not only showed a marked reduction in neutralizing titers against heterologous Sarbecoviruses, but SARS-CoV and WIV-1 challenge in mice resulted in breakthrough infections. Chimeric spike mRNA vaccines efficiently neutralized D614G, mink cluster five, and the UK B.1.1.7 and South African B.1.351 variants of concern. Thus, multiplexed-chimeric spikes can prevent SARS-like zoonotic coronavirus infections with pandemic potential. |Animals[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/immunology[MESH] |Betacoronavirus/*immunology/physiology[MESH] |COVID-19 Vaccines/*immunology[MESH] |COVID-19/prevention & control[MESH] |Coronavirus Infections/immunology/*prevention & control[MESH] |Cross Protection[MESH] |Cytokines/blood[MESH] |Female[MESH] |Immunity, Heterologous[MESH] |Immunogenicity, Vaccine[MESH] |Liposomes[MESH] |Lung/pathology/virology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Nanoparticles[MESH] |Protein Domains[MESH] |Recombinant Fusion Proteins[MESH] |SARS-CoV-2/immunology/physiology[MESH] |Severe Acute Respiratory Syndrome/prevention & control[MESH] |Severe acute respiratory syndrome-related coronavirus/immunology/physiology[MESH] |Spike Glycoprotein, Coronavirus/chemistry/genetics/*immunology[MESH] |Vaccines, Synthetic/*immunology[MESH] |Viral Vaccines/*immunology[MESH] |Virus Replication[MESH]Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in(epmc).pdf DeepDyve Pubget Overpricing