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10.5802/crbiol.53 http://scihub22266oqcxt.onion/10.5802/crbiol.53 34213849!ä!34213849 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       C+R+Biol 2021 ; 344 (1): 77-110 Nephropedia Template TP {{tp|p=34213849|t=2021. Structure-function relations of the SARS-CoV-2 spike protein and impact of mutations in the variants of concern |pdf=|usr=}}{{34213849}} gab.com Text Structure-function relations of the SARS-CoV-2 spike protein and impact of mutations in the variants of concern JO: C R Biol http://www.kidney.de/pget.php?&tw=1&pmid=34213849 #FOAvip This review covers the main features of the severe acquired respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, its interaction with the main entry receptor, the human angiotensin converting enzyme 2 (ACE2), and the subsequent membrane fusion step. The focus is on the structural organization of these proteins and mechanistic aspects of their interactions that lead to cytoplasmic release of the viral genome. The most potently neutralizing antibodies against SARS-CoV-2 were shown to interfere with the spike/ACE2 interaction. I thus also review the location and the potential impact of mutations in the spike protein observed in the variants of concern that emerged concomitantly with acquired immunity in the population after one year of virus circulation. Understanding how these interactions affect the spike/ACE2 interactions and the subsequent spike-protein-induced membrane fusion reaction is important to stay one step ahead of the virus evolution and develop efficient countermeasures. Twit Text FOAVip Structure-function relations of the SARS-CoV-2 spike protein and impact of mutations in the variants of concern ????C R Biol http://www.kidney.de/pget.php?&tw=1&pmid=34213849 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34213849 #FOAvip English Wikipedia <ref>{{Cite pmid|34213849}}</ref> Structure-function relations of the SARS-CoV-2 spike protein and impact of mutations in the variants of concern #MMPMID34213849 Rey F C R Biol 2021[Jun]; 344 (1): 77-110 PMID34213849show ga This review covers the main features of the severe acquired respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, its interaction with the main entry receptor, the human angiotensin converting enzyme 2 (ACE2), and the subsequent membrane fusion step. The focus is on the structural organization of these proteins and mechanistic aspects of their interactions that lead to cytoplasmic release of the viral genome. The most potently neutralizing antibodies against SARS-CoV-2 were shown to interfere with the spike/ACE2 interaction. I thus also review the location and the potential impact of mutations in the spike protein observed in the variants of concern that emerged concomitantly with acquired immunity in the population after one year of virus circulation. Understanding how these interactions affect the spike/ACE2 interactions and the subsequent spike-protein-induced membrane fusion reaction is important to stay one step ahead of the virus evolution and develop efficient countermeasures. |*COVID-19[MESH] |*Spike Glycoprotein, Coronavirus/genetics/metabolism[MESH] |Humans[MESH] |Mutation[MESH] |Protein Binding[MESH]Structure-function relations of the SARS-CoV-2 spike protein and impac(epmc).pdf DeepDyve Pubget Overpricing