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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Eur+J+Pediatr 2022 ; 181 (1): 91-97 Nephropedia Template TP
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Investigation of endothelial dysfunction and arterial stiffness in multisystem inflammatory syndrome in children #MMPMID34212240
Ciftel M; Atas N; Yilmaz O
Eur J Pediatr 2022[Jan]; 181 (1): 91-97 PMID34212240show ga
Severe acute respiratory syndrome coronavirus 2 infection can result in multisystem inflammatory syndrome in children (MIS-C). MIS-C can lead to myocardial dysfunction, heart failure, and multiorgan failure; the primary finding is hyperinflammation. Endothelial dysfunction has not been evaluated in patients with MIS-C. We investigated endothelial dysfunction and arterial stiffness parameters in patients with MIS-C. The study included 38 pediatric patients (20 males and 18 females aged 4-17 years, mean age 8.89 years) with MIS-C. Thirty-eight age- and sex-matched healthy individuals were enrolled as the control group. Systolic and diastolic ventricular measurements and systolic and diastolic measurements of ascending aorta diameter were performed by M-mode echocardiography. Endothelial dysfunction was evaluated using flow-mediated dilation by measuring the brachial artery diameter with a high-resolution probe. The MIS-C group had lower flow-mediated dilation than did the controls. The MIS-C group had decreased aortic strain and aortic distensibility values and correlations between decreased flow-mediated dilation and reduced aortic strain, aortic distensibility, and reduced ejection fraction.Conclusion: The results show that patients with MIS-C had endothelial dysfunction and arterial stiffness. Furthermore, the degree of endothelial dysfunction correlated with reduced ejection fractions.What is Known:*Endothelial dysfunction and arterial stiffness are unknown in patients with MIS-C.*The effect of endothelial dysfunction and arterial stiffness on decreased cardiac function is unknown.What is New:*MIS-C patients have endothelial dysfunction and arterial stiffness.*There is a link between left ventricular dysfunction and reduced endothelial dysfunction in patients with MIS-C.