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10.3389/fimmu.2021.678570 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.678570 34211469!8239432!34211469     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 678570 Nephropedia Template TP {{tp|p=34211469|t=2021. Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses |pdf=|usr=}}{{34211469}} gab.com Text Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34211469 #FOAvip Passive immunization using monoclonal antibodies will play a vital role in the fight against COVID-19. The recent emergence of viral variants with reduced sensitivity to some current antibodies and vaccines highlights the importance of broad cross-reactivity. This study describes deep-mining of the antibody repertoires of hospitalized COVID-19 patients using phage display technology and B cell receptor (BCR) repertoire sequencing to isolate neutralizing antibodies and gain insights into the early antibody response. This comprehensive discovery approach has yielded a panel of potent neutralizing antibodies which bind distinct viral epitopes including epitopes conserved in SARS-CoV-1. Structural determination of a non-ACE2 receptor blocking antibody reveals a previously undescribed binding epitope, which is unlikely to be affected by the mutations in any of the recently reported major viral variants including B.1.1.7 (from the UK), B.1.351 (from South Africa) and B.1.1.28 (from Brazil). Finally, by combining sequences of the RBD binding and neutralizing antibodies with the B cell receptor repertoire sequencing, we also describe a highly convergent early antibody response. Similar IgM-derived sequences occur within this study group and also within patient responses described by multiple independent studies published previously. Twit Text FOAVip Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34211469 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34211469 #FOAvip English Wikipedia <ref>{{Cite pmid|34211469}}</ref> Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses #MMPMID34211469 Bullen G; Galson JD; Hall G; Villar P; Moreels L; Ledsgaard L; Mattiuzzo G; Bentley EM; Masters EW; Tang D; Millett S; Tongue D; Brown R; Diamantopoulos I; Parthiban K; Tebbutt C; Leah R; Chaitanya K; Ergueta-Carballo S; Pazeraitis D; Surade SB; Ashiru O; Crippa L; Cowan R; Bowler MW; Campbell JI; Lee WJ; Carr MD; Matthews D; Pfeffer P; Hufton SE; Sawmynaden K; Osbourn J; McCafferty J; Karatt-Vellatt A Front Immunol 2021[]; 12 (ä): 678570 PMID34211469show ga Passive immunization using monoclonal antibodies will play a vital role in the fight against COVID-19. The recent emergence of viral variants with reduced sensitivity to some current antibodies and vaccines highlights the importance of broad cross-reactivity. This study describes deep-mining of the antibody repertoires of hospitalized COVID-19 patients using phage display technology and B cell receptor (BCR) repertoire sequencing to isolate neutralizing antibodies and gain insights into the early antibody response. This comprehensive discovery approach has yielded a panel of potent neutralizing antibodies which bind distinct viral epitopes including epitopes conserved in SARS-CoV-1. Structural determination of a non-ACE2 receptor blocking antibody reveals a previously undescribed binding epitope, which is unlikely to be affected by the mutations in any of the recently reported major viral variants including B.1.1.7 (from the UK), B.1.351 (from South Africa) and B.1.1.28 (from Brazil). Finally, by combining sequences of the RBD binding and neutralizing antibodies with the B cell receptor repertoire sequencing, we also describe a highly convergent early antibody response. Similar IgM-derived sequences occur within this study group and also within patient responses described by multiple independent studies published previously. |Antibodies, Monoclonal/immunology/*therapeutic use[MESH] |Antibodies, Neutralizing/immunology/*therapeutic use[MESH] |Antibodies, Viral/immunology[MESH] |COVID-19 Serotherapy[MESH] |COVID-19/immunology/*prevention & control/*therapy[MESH] |Cell Surface Display Techniques/methods[MESH] |Data Mining/methods[MESH] |Epitopes/immunology[MESH] |Humans[MESH] |Immunization, Passive/methods[MESH] |SARS-CoV-2/*immunology[MESH]Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of (epmc).pdf DeepDyve Pubget Overpricing