Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1038/s41598-021-92940-3

http://scihub22266oqcxt.onion/10.1038/s41598-021-92940-3
suck pdf from google scholar
34211037!8249624!34211037
unlimited free pdf from europmc34211037    free
PDF from PMC    free
html from PMC    free

Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34211037&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215

suck abstract from ncbi

pmid34211037      Sci+Rep 2021 ; 11 (1): 13638
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • The RNA sensor MDA5 detects SARS-CoV-2 infection #MMPMID34211037
  • Sampaio NG; Chauveau L; Hertzog J; Bridgeman A; Fowler G; Moonen JP; Dupont M; Russell RA; Noerenberg M; Rehwinkel J
  • Sci Rep 2021[Jul]; 11 (1): 13638 PMID34211037show ga
  • Human cells respond to infection by SARS-CoV-2, the virus that causes COVID-19, by producing cytokines including type I and III interferons (IFNs) and proinflammatory factors such as IL6 and TNF. IFNs can limit SARS-CoV-2 replication but cytokine imbalance contributes to severe COVID-19. We studied how cells detect SARS-CoV-2 infection. We report that the cytosolic RNA sensor MDA5 was required for type I and III IFN induction in the lung cancer cell line Calu-3 upon SARS-CoV-2 infection. Type I and III IFN induction further required MAVS and IRF3. In contrast, induction of IL6 and TNF was independent of the MDA5-MAVS-IRF3 axis in this setting. We further found that SARS-CoV-2 infection inhibited the ability of cells to respond to IFNs. In sum, we identified MDA5 as a cellular sensor for SARS-CoV-2 infection that induced type I and III IFNs.
  • |COVID-19/*immunology[MESH]
  • |Cell Line[MESH]
  • |Humans[MESH]
  • |Immunity, Innate[MESH]
  • |Interferon Lambda[MESH]
  • |Interferon Type I/*immunology[MESH]
  • |Interferon-Induced Helicase, IFIH1/*immunology[MESH]
  • |Interferons/*immunology[MESH]
  • |RNA/immunology[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box