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10.1126/science.abi7994 http://scihub22266oqcxt.onion/10.1126/science.abi7994 34210893!9835956!34210893     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2021 ; 373 (6555): 648-654 Nephropedia Template TP {{tp|p=34210893|t=2021. SARS-CoV-2 immune evasion by the B 1 427/B 1 429 variant of concern |pdf=|usr=}}{{34210893}} gab.com Text SARS-CoV-2 immune evasion by the B 1 427/B 1 429 variant of concern JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=34210893 #FOAvip A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C in the N-terminal domain (NTD), and L452R in the receptor-binding domain (RBD). Plasma from individuals vaccinated with a Wuhan-1 isolate-based messenger RNA vaccine or from convalescent individuals exhibited neutralizing titers that were reduced 2- to 3.5-fold against the B.1.427/B.1.429 variant relative to wild-type pseudoviruses. The L452R mutation reduced neutralizing activity in 14 of 34 RBD-specific monoclonal antibodies (mAbs). The S13I and W152C mutations resulted in total loss of neutralization for 10 of 10 NTD-specific mAbs because the NTD antigenic supersite was remodeled by a shift of the signal peptide cleavage site and the formation of a new disulfide bond, as revealed by mass spectrometry and structural studies. Twit Text FOAVip SARS-CoV-2 immune evasion by the B 1 427/B 1 429 variant of concern ????Science http://www.kidney.de/pget.php?&tw=1&pmid=34210893 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34210893 #FOAvip English Wikipedia <ref>{{Cite pmid|34210893}}</ref> SARS-CoV-2 immune evasion by the B 1 427/B 1 429 variant of concern #MMPMID34210893 McCallum M; Bassi J; De Marco A; Chen A; Walls AC; Di Iulio J; Tortorici MA; Navarro MJ; Silacci-Fregni C; Saliba C; Sprouse KR; Agostini M; Pinto D; Culap K; Bianchi S; Jaconi S; Cameroni E; Bowen JE; Tilles SW; Pizzuto MS; Guastalla SB; Bona G; Pellanda AF; Garzoni C; Van Voorhis WC; Rosen LE; Snell G; Telenti A; Virgin HW; Piccoli L; Corti D; Veesler D Science 2021[Aug]; 373 (6555): 648-654 PMID34210893show ga A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C in the N-terminal domain (NTD), and L452R in the receptor-binding domain (RBD). Plasma from individuals vaccinated with a Wuhan-1 isolate-based messenger RNA vaccine or from convalescent individuals exhibited neutralizing titers that were reduced 2- to 3.5-fold against the B.1.427/B.1.429 variant relative to wild-type pseudoviruses. The L452R mutation reduced neutralizing activity in 14 of 34 RBD-specific monoclonal antibodies (mAbs). The S13I and W152C mutations resulted in total loss of neutralization for 10 of 10 NTD-specific mAbs because the NTD antigenic supersite was remodeled by a shift of the signal peptide cleavage site and the formation of a new disulfide bond, as revealed by mass spectrometry and structural studies. |*Immune Evasion[MESH] |2019-nCoV Vaccine mRNA-1273[MESH] |Amino Acid Substitution[MESH] |Antibodies, Monoclonal/immunology[MESH] |Antibodies, Neutralizing/blood/immunology[MESH] |Antibodies, Viral/blood/immunology[MESH] |Antigens, Viral/immunology[MESH] |BNT162 Vaccine[MESH] |COVID-19 Vaccines/immunology[MESH] |COVID-19/immunology/*virology[MESH] |Cryoelectron Microscopy[MESH] |Humans[MESH] |Models, Molecular[MESH] |Mutation[MESH] |Neutralization Tests[MESH] |Protein Conformation[MESH] |Protein Domains[MESH] |Protein Interaction Domains and Motifs[MESH] |Protein Subunits/chemistry[MESH] |SARS-CoV-2/genetics/*immunology/*pathogenicity[MESH]SARS-CoV-2 immune evasion by the B 1 427/B 1 429 variant of concern (epmc).pdf DeepDyve Pubget Overpricing