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10.1183/13993003.00996-2021

http://scihub22266oqcxt.onion/10.1183/13993003.00996-2021
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suck abstract from ncbi

pmid34210791      Eur+Respir+J 2021 ; 58 (2): ?
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  • Cardiopulmonary exercise capacity and limitations 3 months after COVID-19 hospitalisation #MMPMID34210791
  • Skjorten I; Ankerstjerne OAW; Trebinjac D; Bronstad E; Rasch-Halvorsen O; Einvik G; Lerum TV; Stavem K; Edvardsen A; Ingul CB
  • Eur Respir J 2021[Aug]; 58 (2): ? PMID34210791show ga
  • BACKGROUND: This study aimed to describe cardiopulmonary function during exercise 3 months after hospital discharge for COVID-19 and compare groups according to dyspnoea and intensive care unit (ICU) stay. METHODS: Participants with COVID-19 discharged from five large Norwegian hospitals were consecutively invited to a multicentre, prospective cohort study. In total, 156 participants (mean age 56.2 years, 60 females) were examined with a cardiopulmonary exercise test (CPET) 3 months after discharge and compared with a reference population. Dyspnoea was assessed using the modified Medical Research Council (mMRC) dyspnoea scale. RESULTS: Peak oxygen uptake (V'(O(2 )) (peak)) <80% predicted was observed in 31% (n=49). Ventilatory efficiency was reduced in 15% (n=24), while breathing reserve <15% was observed in 16% (n=25). Oxygen pulse <80% predicted was found in 18% (n=28). Dyspnoea (mMRC >/=1) was reported by 47% (n=59). These participants had similar V'(O(2 )) (peak) (p=0.10) but lower mean+/-sd V'(O(2 )) (peak).kg(-1) % predicted compared with participants without dyspnoea (mMRC 0) (76+/-16% versus 89+/-18%; p=0.009) due to higher body mass index (p=0.03). For ICU- versus non-ICU-treated participants, mean+/-sd V'(O(2 )) (peak) % predicted was 82+/-15% and 90+/-17% (p=0.004), respectively. Ventilation, breathing reserve and ventilatory efficiency were similar between the ICU and non-ICU groups. CONCLUSIONS: One-third of participants experienced V'(O(2 )) (peak) <80% predicted 3 months after hospital discharge for COVID-19. Dyspnoeic participants were characterised by lower exercise capacity due to obesity and lower ventilatory efficiency. Ventilation and ventilatory efficiency were similar between ICU- and non-ICU-treated participants.
  • |*COVID-19[MESH]
  • |*Exercise Tolerance[MESH]
  • |Exercise Test[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Middle Aged[MESH]
  • |Oxygen Consumption[MESH]
  • |Prospective Studies[MESH]


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