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10.1126/sciimmunol.abg5669 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abg5669 34210785!8975171!34210785     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2021 ; 6 (61): ä Nephropedia Template TP {{tp|p=34210785|t=2021. CD8(+) T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients |pdf=|usr=}}{{34210785}} gab.com Text CD8(+) T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34210785 #FOAvip A central feature of the SARS-CoV-2 pandemic is that some individuals become severely ill or die, whereas others have only a mild disease course or are asymptomatic. Here we report development of an improved multimeric alphabeta T cell staining reagent platform, with each maxi-ferritin "spheromer" displaying 12 peptide-MHC complexes. Spheromers stain specific T cells more efficiently than peptide-MHC tetramers and capture a broader portion of the sequence repertoire for a given peptide-MHC. Analyzing the response in unexposed individuals, we find that T cells recognizing peptides conserved amongst coronaviruses are more abundant and tend to have a "memory" phenotype, compared to those unique to SARS-CoV-2. Significantly, CD8(+) T cells with these conserved specificities are much more abundant in COVID-19 patients with mild disease versus those with a more severe illness, suggesting a protective role. Twit Text FOAVip CD8(+) T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34210785 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34210785 #FOAvip English Wikipedia <ref>{{Cite pmid|34210785}}</ref> CD8(+) T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients #MMPMID34210785 Mallajosyula V; Ganjavi C; Chakraborty S; McSween AM; Pavlovitch-Bedzyk AJ; Wilhelmy J; Nau A; Manohar M; Nadeau KC; Davis MM Sci Immunol 2021[Jul]; 6 (61): ä PMID34210785show ga A central feature of the SARS-CoV-2 pandemic is that some individuals become severely ill or die, whereas others have only a mild disease course or are asymptomatic. Here we report development of an improved multimeric alphabeta T cell staining reagent platform, with each maxi-ferritin "spheromer" displaying 12 peptide-MHC complexes. Spheromers stain specific T cells more efficiently than peptide-MHC tetramers and capture a broader portion of the sequence repertoire for a given peptide-MHC. Analyzing the response in unexposed individuals, we find that T cells recognizing peptides conserved amongst coronaviruses are more abundant and tend to have a "memory" phenotype, compared to those unique to SARS-CoV-2. Significantly, CD8(+) T cells with these conserved specificities are much more abundant in COVID-19 patients with mild disease versus those with a more severe illness, suggesting a protective role. |*Severity of Illness Index[MESH] |CD8-Positive T-Lymphocytes/*immunology/pathology[MESH] |COVID-19/*immunology/pathology[MESH] |Epitopes, T-Lymphocyte/*immunology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH]CD8(+) T cells specific for conserved coronavirus epitopes correlate w(epmc).pdf DeepDyve Pubget Overpricing