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10.1016/j.resinv.2021.06.003

http://scihub22266oqcxt.onion/10.1016/j.resinv.2021.06.003
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34210623!8214200!34210623
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suck abstract from ncbi


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pmid34210623      Respir+Investig 2021 ; 59 (5): 635-642
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  • Side effects and antibody titer transition of the BNT162b2 messenger ribonucleic acid coronavirus disease 2019 vaccine in Japan #MMPMID34210623
  • Izumo T; Kuse N; Awano N; Tone M; Sakamoto K; Takada K; Muto Y; Fujimoto K; Saiki A; Ito Y; Matsumoto H; Inomata M
  • Respir Investig 2021[Sep]; 59 (5): 635-642 PMID34210623show ga
  • BACKGROUND: The coronavirus disease (COVID-19) has afflicted large populations worldwide. Although vaccines aroused great expectations, their side effects on Japanese people and the antibody titer transition after vaccination are unclear. METHODS: The side effects of the BNT162b2 mRNA COVID-19 vaccine in participants who received vaccination at our center were investigated. Some participants were also surveyed for the antibody titer transition. RESULTS: In this study, 983 and 798 Japanese participants responded to the first and second doses, respectively. Side effects occurred in 757 (77.0%) and 715 participants (90.0%) after the first and second doses, respectively. No Grade 4 side effects occurred. The second dose had significantly more side effects than the first dose (p < 0.001). Side effects occurred after the second dose in 571 female (92.1%) and 178 male participants (80.1%). Female participants had a higher incidence of side effects than the male participants (p < 0.001). A comparison among the age groups showed significant differences (p = 0.018), and the frequency of side effects decreased with age. Twenty-three individuals participated in the survey of antibody titer transition. After the second vaccine dose, the median antibody titers for IgG and IgM were 3.76 and 0.07 AU/mL, respectively. Both IgG and IgM titers showed a significant increase over the study period (p < 0.001). CONCLUSIONS: The BNT162b2 mRNA COVID-19 vaccine might be safe for Japanese people, and the antibody titer increased with two doses of vaccination. Larger nationwide studies are warranted to verify these findings.
  • |*COVID-19[MESH]
  • |*COVID-19 Vaccines[MESH]
  • |BNT162 Vaccine[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Japan/epidemiology[MESH]
  • |Male[MESH]
  • |RNA, Messenger[MESH]
  • |RNA, Viral[MESH]


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