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10.1186/s12879-021-06354-7

http://scihub22266oqcxt.onion/10.1186/s12879-021-06354-7
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suck abstract from ncbi


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pmid34210280      BMC+Infect+Dis 2021 ; 21 (1): 631
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  • Lymphocyte subset alterations with disease severity, imaging manifestation, and delayed hospitalization in COVID-19 patients #MMPMID34210280
  • Wu D; Wu X; Huang J; Rao Q; Zhang Q; Zhang W
  • BMC Infect Dis 2021[Jul]; 21 (1): 631 PMID34210280show ga
  • BACKGROUND: COVID-19 continuously threated public health heavily. Present study aimed to investigate the lymphocyte subset alterations with disease severity, imaging manifestation, and delayed hospitalization in COVID-19 patients. METHODS: Lymphocyte subsets was classified using flow cytometry with peripheral blood collected from 106 patients. RESULTS: Multivariate logistic regression showed that chest tightness, lymphocyte count, and gamma-glutamyl transpeptidase were the independent predictors for severe COVID-19. The T cell, CD4(+) T cell and B cell counts in severe patients were significantly lower than that in mild patients (p = 0.004, 0.003 and 0.046, respectively). Only the T cell count was gradually decreased with the increase of infiltrated quadrants of lesions in computed tomography (CT) (p = 0.043). The T cell, CD4(+) T cell, and CD8(+) T cell counts were gradually decreased with the increase of infiltrated area of the maximum lesion in CT (p = 0.002, 0.003, 0.028; respectively). For severe patients, the counts of T cell, CD4(+) T cell, CD8(+) T cell gradually decreased with the increased delayed hospitalization (p = 0.001, 0.03, and < 0.001, respectively). The proportions of T cell, CD8(+) T cell gradually decreased with the increased delayed hospitalization (both p < 0.001), but the proportions of NK cell, B cell gradually increased with the increased delayed hospitalization (p = 0.007, and 0.002, respectively). For mild patients, only the NK cell count was gradually decreased with the increased delayed hospitalization (p = 0.012). CONCLUSION: T lymphocyte and its subset negatively correlated with disease severity, CT manifestation and delayed hospitalization. The counts of lymphocyte subset were changed more profound than their proportions.
  • |*Lymphocyte Subsets[MESH]
  • |*SARS-CoV-2[MESH]
  • |Adult[MESH]
  • |B-Lymphocytes[MESH]
  • |COVID-19/*diagnostic imaging/*pathology[MESH]
  • |Diagnostic Tests, Routine[MESH]
  • |Flow Cytometry[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Killer Cells, Natural[MESH]
  • |Logistic Models[MESH]
  • |Lymphocyte Count[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]


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