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10.3390/ijms22137017 http://scihub22266oqcxt.onion/10.3390/ijms22137017 34209845!8268312!34209845     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (13): ä Nephropedia Template TP {{tp|p=34209845|t=2021. Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators |pdf=|usr=}}{{34209845}} gab.com Text Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34209845 #FOAvip The vulnerability of humankind to SARS-CoV-2 in the absence of a pre-existing immunity, the unpredictability of the infection outcome, and the high transmissibility, broad tissue tropism, and ability to exploit and subvert the immune response pose a major challenge and are likely perpetuating the COVID-19 pandemic. Nevertheless, this peculiar infectious scenario provides researchers with a unique opportunity for studying, with the latest immunological techniques and understandings, the immune response in SARS-CoV-2 naive versus recovered subjects as well as in SARS-CoV-2 vaccinees. Interestingly, the current understanding of COVID-19 indicates that the combined action of innate immune cells, cytokines, and chemokines fine-tunes the outcome of SARS-CoV-2 infection and the related immunopathogenesis. Indeed, the emerging picture clearly shows that the excessive inflammatory response against this virus is among the main causes of disease severity in COVID-19 patients. In this review, the innate immune response to SARS-CoV-2 infection is described not only in light of its capacity to influence the adaptive immune response towards a protective phenotype but also with the intent to point out the multiple strategies exploited by SARS-CoV-2 to antagonize host antiviral response and, finally, to outline inborn errors predisposing individuals to COVID-19 disease severity. Twit Text FOAVip Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34209845 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34209845 #FOAvip English Wikipedia <ref>{{Cite pmid|34209845}}</ref> Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators #MMPMID34209845 Ricci D; Etna MP; Rizzo F; Sandini S; Severa M; Coccia EM Int J Mol Sci 2021[Jun]; 22 (13): ä PMID34209845show ga The vulnerability of humankind to SARS-CoV-2 in the absence of a pre-existing immunity, the unpredictability of the infection outcome, and the high transmissibility, broad tissue tropism, and ability to exploit and subvert the immune response pose a major challenge and are likely perpetuating the COVID-19 pandemic. Nevertheless, this peculiar infectious scenario provides researchers with a unique opportunity for studying, with the latest immunological techniques and understandings, the immune response in SARS-CoV-2 naive versus recovered subjects as well as in SARS-CoV-2 vaccinees. Interestingly, the current understanding of COVID-19 indicates that the combined action of innate immune cells, cytokines, and chemokines fine-tunes the outcome of SARS-CoV-2 infection and the related immunopathogenesis. Indeed, the emerging picture clearly shows that the excessive inflammatory response against this virus is among the main causes of disease severity in COVID-19 patients. In this review, the innate immune response to SARS-CoV-2 infection is described not only in light of its capacity to influence the adaptive immune response towards a protective phenotype but also with the intent to point out the multiple strategies exploited by SARS-CoV-2 to antagonize host antiviral response and, finally, to outline inborn errors predisposing individuals to COVID-19 disease severity. |*Immunity, Innate[MESH] |COVID-19/immunology/*pathology/virology[MESH] |Chemokines/metabolism[MESH] |Cytokines/metabolism[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Killer Cells, Natural/cytology/metabolism[MESH] |Monocytes/cytology/metabolism[MESH] |SARS-CoV-2/isolation & purification[MESH]Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble (epmc).pdf DeepDyve Pubget Overpricing