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10.3390/ijms22136984 http://scihub22266oqcxt.onion/10.3390/ijms22136984 34209586!8268482!34209586     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (13): ä Nephropedia Template TP {{tp|p=34209586|t=2021. NLRP3 and Infections: beta-Amyloid in Inflammasome beyond Neurodegeneration |pdf=|usr=}}{{34209586}} gab.com Text NLRP3 and Infections: beta-Amyloid in Inflammasome beyond Neurodegeneration JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34209586 #FOAvip Amyloid beta (Abeta)-induced abnormal neuroinflammation is recognized as a major pathological feature of Alzheimer's disease (AD), which results in memory impairment. Research exploring low-grade systemic inflammation and its impact on the development and progression of neurodegenerative disease has increased. A particular research focus has been whether systemic inflammation arises only as a secondary effect of disease, or it is also a cause of pathology. The inflammasomes, and more specifically the NLRP3 inflammasome, are crucial components of the innate immune system and are usually activated in response to infection or tissue damage. Although inflammasome activation plays critical roles against various pathogens in host defense, overactivation of inflammasome contributes to the pathogenesis of inflammatory diseases, including acute central nervous system (CNS) injuries and chronic neurodegenerative diseases, such as AD. This review summarizes the current literature on the role of the NLRP3 inflammasome in the pathogenesis of AD, and its involvement in infections, particularly SARS-CoV-2. NLRP3 might represent the crossroad between the hypothesized neurodegeneration and the primary COVID-19 infection. Twit Text FOAVip NLRP3 and Infections: beta-Amyloid in Inflammasome beyond Neurodegeneration ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34209586 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34209586 #FOAvip English Wikipedia <ref>{{Cite pmid|34209586}}</ref> NLRP3 and Infections: beta-Amyloid in Inflammasome beyond Neurodegeneration #MMPMID34209586 Sita G; Graziosi A; Hrelia P; Morroni F Int J Mol Sci 2021[Jun]; 22 (13): ä PMID34209586show ga Amyloid beta (Abeta)-induced abnormal neuroinflammation is recognized as a major pathological feature of Alzheimer's disease (AD), which results in memory impairment. Research exploring low-grade systemic inflammation and its impact on the development and progression of neurodegenerative disease has increased. A particular research focus has been whether systemic inflammation arises only as a secondary effect of disease, or it is also a cause of pathology. The inflammasomes, and more specifically the NLRP3 inflammasome, are crucial components of the innate immune system and are usually activated in response to infection or tissue damage. Although inflammasome activation plays critical roles against various pathogens in host defense, overactivation of inflammasome contributes to the pathogenesis of inflammatory diseases, including acute central nervous system (CNS) injuries and chronic neurodegenerative diseases, such as AD. This review summarizes the current literature on the role of the NLRP3 inflammasome in the pathogenesis of AD, and its involvement in infections, particularly SARS-CoV-2. NLRP3 might represent the crossroad between the hypothesized neurodegeneration and the primary COVID-19 infection. |Alzheimer Disease/metabolism/*pathology[MESH] |Amyloid beta-Peptides/*metabolism[MESH] |Animals[MESH] |Coronavirus/pathogenicity[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Inflammasomes/*metabolism[MESH] |Microglia/metabolism[MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism[MESH]NLRP3 and Infections: beta-Amyloid in Inflammasome beyond Neurodegener(epmc).pdf DeepDyve Pubget Overpricing