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10.3390/v13061102 http://scihub22266oqcxt.onion/10.3390/v13061102 34207696!8228270!34207696     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2021 ; 13 (6): ä Nephropedia Template TP {{tp|p=34207696|t=2021. HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response |pdf=|usr=}}{{34207696}} gab.com Text HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34207696 #FOAvip Mammalian cells have developed an elaborate network of immunoproteins that serve to identify and combat viral pathogens. Interferon-stimulated gene 15 (ISG15) is a 15.2 kDa tandem ubiquitin-like protein (UBL) that is used by specific E1-E2-E3 ubiquitin cascade enzymes to interfere with the activity of viral proteins. Recent biochemical studies have demonstrated how the E3 ligase HECT and RCC1-containing protein 5 (HERC5) regulates ISG15 signaling in response to hepatitis C (HCV), influenza-A (IAV), human immunodeficiency virus (HIV), SARS-CoV-2 and other viral infections. Taken together, the potent antiviral activity displayed by HERC5 and ISG15 make them promising drug targets for the development of novel antiviral therapeutics that can augment the host antiviral response. In this review, we examine the emerging role of ISG15 in antiviral immunity with a particular focus on how HERC5 orchestrates the specific and timely ISGylation of viral proteins in response to infection. Twit Text FOAVip HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34207696 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34207696 #FOAvip English Wikipedia <ref>{{Cite pmid|34207696}}</ref> HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response #MMPMID34207696 Mathieu NA; Paparisto E; Barr SD; Spratt DE Viruses 2021[Jun]; 13 (6): ä PMID34207696show ga Mammalian cells have developed an elaborate network of immunoproteins that serve to identify and combat viral pathogens. Interferon-stimulated gene 15 (ISG15) is a 15.2 kDa tandem ubiquitin-like protein (UBL) that is used by specific E1-E2-E3 ubiquitin cascade enzymes to interfere with the activity of viral proteins. Recent biochemical studies have demonstrated how the E3 ligase HECT and RCC1-containing protein 5 (HERC5) regulates ISG15 signaling in response to hepatitis C (HCV), influenza-A (IAV), human immunodeficiency virus (HIV), SARS-CoV-2 and other viral infections. Taken together, the potent antiviral activity displayed by HERC5 and ISG15 make them promising drug targets for the development of novel antiviral therapeutics that can augment the host antiviral response. In this review, we examine the emerging role of ISG15 in antiviral immunity with a particular focus on how HERC5 orchestrates the specific and timely ISGylation of viral proteins in response to infection. |Animals[MESH] |COVID-19/immunology[MESH] |Cytokines/*genetics/immunology[MESH] |HeLa Cells[MESH] |Humans[MESH] |Interferons/*immunology[MESH] |Intracellular Signaling Peptides and Proteins/*genetics/immunology[MESH] |Mice[MESH] |SARS-CoV-2/immunology[MESH] |Ubiquitins/*genetics/immunology[MESH] |Viral Proteins/genetics/metabolism[MESH]HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral(epmc).pdf DeepDyve Pubget Overpricing