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10.3390/medicina57060594

http://scihub22266oqcxt.onion/10.3390/medicina57060594
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34207689!8227321!34207689
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suck abstract from ncbi


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pmid34207689      Medicina+(Kaunas) 2021 ; 57 (6): ä
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  • Elevated Procalcitonin Is Positively Associated with the Severity of COVID-19: A Meta-Analysis Based on 10 Cohort Studies #MMPMID34207689
  • Shen Y; Cheng C; Zheng X; Jin Y; Duan G; Chen M; Chen S
  • Medicina (Kaunas) 2021[Jun]; 57 (6): ä PMID34207689show ga
  • Background and Objectives: Procalcitonin (PCT) is positively associated with the severity of COVID-19 (including severe, critical, or fatal outcomes), but some of the confounding factors are not considered. The aim of this meta-analysis was to estimate the adjusted relationship between elevated procalcitonin on admission and the severity of COVID-19. Materials and Methods: We searched 1805 articles from PubMed, Web of Science, and Embase databases up to 2 April 2021. The articles were selected which reported the adjusted relationship applying multivariate analysis between PCT and the severity of COVID-19. The pooled effect estimate was calculated by the random-effects model. Results: The meta-analysis included 10 cohort studies with a total of 7716 patients. Patients with elevated procalcitonin on admission were at a higher risk of severe and critical COVID-19 (pooled effect estimate: 1.77, 95% confidence interval (CI): 1.38-2.29; I(2) = 85.6%, p < 0.001). Similar results were also observed in dead patients (pooled effect estimate: 1.77, 95% CI: 1.36-2.30). After adjusting for diabetes, the positive association between PCT and the severity of COVID-19 decreased. Subgroup analysis revealed heterogeneity between studies and sensitivity analysis showed that the results were robust. There was no evidence of publication bias by Egger's test (p = 0.106). Conclusions: Higher procalcitonin is positively associated with the severity of COVID-19, which is a potential biomarker to evaluate the severity of COVID-19 and predict the prognosis.
  • |*COVID-19[MESH]
  • |*Procalcitonin[MESH]
  • |Cohort Studies[MESH]
  • |Humans[MESH]
  • |Prognosis[MESH]


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