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10.3390/nu13072129 http://scihub22266oqcxt.onion/10.3390/nu13072129 34206219!8308267!34206219     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nutrients 2021 ; 13 (7): ä Nephropedia Template TP {{tp|p=34206219|t=2021. Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients |pdf=|usr=}}{{34206219}} gab.com Text Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients JO: Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=34206219 #FOAvip (1) Background: Vitamin D, a well-established regulator of calcium and phosphate metabolism, also has immune-modulatory functions. An uncontrolled immune response and cytokine storm are tightly linked to fatal courses of COVID-19. The present retrospective study aimed to inves-tigate vitamin D status markers and vitamin D degradation products in a mixed cohort of 148 hospitalized COVID-19 patients with various clinical courses of COVID-19. (2) Methods: The serum concentrations of 25(OH)D(3), 25(OH)D(2), 24,25(OH)(2)D(3), and 25,26(OH)(2)D(3) were determined by a validated liquid-chromatography tandem mass-spectrometry method in leftover serum samples from 148 COVID-19 patients that were admitted to the University Hospital of the Medical Uni-versity of Graz between April and November 2020. Anthropometric and clinical data, as well as outcomes were obtained from the laboratory and hospital information systems. (3) Results: From the 148 patients, 34 (23%) died within 30 days after admission. The frequency of fatal outcomes did not differ between males and females. Non-survivors were significantly older than survivors, had higher peak concentrations of IL-6 and CRP, and required mechanical ventilation more frequently. The serum concentrations of all vitamin D metabolites and the vitamin D metabolite ratio (VMR) did not differ significantly between survivors and non-survivors. Additionally, the need for res-piratory support was unrelated to the serum concentrations of 25(OH)D vitamin D and the two vitamin D catabolites, as well as the VMR. (4) Conclusion: The present results do not support a relevant role of vitamin D for the course and outcome of COVID-19. Twit Text FOAVip Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients ????Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=34206219 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34206219 #FOAvip English Wikipedia <ref>{{Cite pmid|34206219}}</ref> Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients #MMPMID34206219 Zelzer S; Pruller F; Curcic P; Sloup Z; Holter M; Herrmann M; Mangge H Nutrients 2021[Jun]; 13 (7): ä PMID34206219show ga (1) Background: Vitamin D, a well-established regulator of calcium and phosphate metabolism, also has immune-modulatory functions. An uncontrolled immune response and cytokine storm are tightly linked to fatal courses of COVID-19. The present retrospective study aimed to inves-tigate vitamin D status markers and vitamin D degradation products in a mixed cohort of 148 hospitalized COVID-19 patients with various clinical courses of COVID-19. (2) Methods: The serum concentrations of 25(OH)D(3), 25(OH)D(2), 24,25(OH)(2)D(3), and 25,26(OH)(2)D(3) were determined by a validated liquid-chromatography tandem mass-spectrometry method in leftover serum samples from 148 COVID-19 patients that were admitted to the University Hospital of the Medical Uni-versity of Graz between April and November 2020. Anthropometric and clinical data, as well as outcomes were obtained from the laboratory and hospital information systems. (3) Results: From the 148 patients, 34 (23%) died within 30 days after admission. The frequency of fatal outcomes did not differ between males and females. Non-survivors were significantly older than survivors, had higher peak concentrations of IL-6 and CRP, and required mechanical ventilation more frequently. The serum concentrations of all vitamin D metabolites and the vitamin D metabolite ratio (VMR) did not differ significantly between survivors and non-survivors. Additionally, the need for res-piratory support was unrelated to the serum concentrations of 25(OH)D vitamin D and the two vitamin D catabolites, as well as the VMR. (4) Conclusion: The present results do not support a relevant role of vitamin D for the course and outcome of COVID-19. |*Hospitalization[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Biomarkers/blood[MESH] |COVID-19/*blood/*mortality[MESH] |Chromatography, Liquid/methods[MESH] |Ergocalciferols/blood[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Respiration, Artificial/statistics & numerical data[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH] |Tandem Mass Spectrometry/methods[MESH] |Vitamin D Deficiency/blood[MESH] |Vitamin D/analogs & derivatives/*blood[MESH]Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Pa(epmc).pdf DeepDyve Pubget Overpricing