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10.3390/jcm10122642

http://scihub22266oqcxt.onion/10.3390/jcm10122642
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suck abstract from ncbi


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pmid34204014      J+Clin+Med 2021 ; 10 (12): ä
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  • Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Withdrawal Is Associated with Higher Mortality in Hospitalized Patients with COVID-19 #MMPMID34204014
  • Roy-Vallejo E; Sanchez Purificacion A; Torres Pena JD; Sanchez Moreno B; Arnalich F; Garcia Blanco MJ; Lopez Miranda J; Romero-Cabrera JL; Herrero Gil CR; Bascunana J; Rubio-Rivas M; Pintos Otero S; Martinez Sempere V; Ballano Rodriguez-Solis J; Gil Sanchez R; Luque Del Pino J; Gonzalez Noya A; Navas-Alcantara MS; Cortes Rodriguez B; Alcala JN; Suarez-Lombrana A; Andres Soler J; Gomez-Huelgas R; Casas-Rojo JM; Millan Nunez-Cortes J; On Behalf Of The Semi-Covid-Network
  • J Clin Med 2021[Jun]; 10 (12): ä PMID34204014show ga
  • Our main aim was to describe the effect on the severity of ACEI (angiotensin-converting enzyme inhibitor) and ARB (angiotensin II receptor blocker) during COVID-19 hospitalization. A retrospective, observational, multicenter study evaluating hospitalized patients with COVID-19 treated with ACEI/ARB. The primary endpoint was the incidence of the composite outcome of prognosis (IMV (invasive mechanical ventilation), NIMV (non-invasive mechanical ventilation), ICU admission (intensive care unit), and/or all-cause mortality). We evaluated both outcomes in patients whose treatment with ACEI/ARB was continued or withdrawn. Between February and June 2020, 11,205 patients were included, mean age 67 years (SD = 16.3) and 43.1% female; 2162 patients received ACEI/ARB treatment. ACEI/ARB treatment showed lower all-cause mortality (p < 0.0001). Hypertensive patients in the ACEI/ARB group had better results in IMV, ICU admission, and the composite outcome of prognosis (p < 0.0001 for all). No differences were found in the incidence of major adverse cardiovascular events. Patients previously treated with ACEI/ARB continuing treatment during hospitalization had a lower incidence of the composite outcome of prognosis than those whose treatment was withdrawn (RR 0.67, 95%CI 0.63-0.76). ARB was associated with better survival than ACEI (HR 0.77, 95%CI 0.62-0.96). ACEI/ARB treatment during COVID-19 hospitalization was associated with protection on mortality. The benefits were greater in hypertensive, those who continued treatment, and those taking ARB.
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