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10.3390/jpm11060558 http://scihub22266oqcxt.onion/10.3390/jpm11060558 34203982!8232773!34203982     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Pers+Med 2021 ; 11 (6): ä Nephropedia Template TP {{tp|p=34203982|t=2021. Severe COVID-19 in Hospitalized Carriers of Single CFTR Pathogenic Variants |pdf=|usr=}}{{34203982}} gab.com Text Severe COVID-19 in Hospitalized Carriers of Single CFTR Pathogenic Variants JO: J Pers Med http://www.kidney.de/pget.php?&tw=1&pmid=34203982 #FOAvip The clinical presentation of COVID-19 is extremely heterogeneous, ranging from asymptomatic to severely ill patients. Thus, host genetic factors may be involved in determining disease presentation and progression. Given that carriers of single cystic fibrosis (CF)-causing variants of the CFTR gene-CF-carriers-are more susceptible to respiratory tract infections, our aim was to determine their likelihood of undergoing severe COVID-19. We implemented a cohort study of 874 individuals diagnosed with COVID-19, during the first pandemic wave in Italy. Whole exome sequencing was performed and validated CF-causing variants were identified. Forty subjects (16 females and 24 males) were found to be CF-carriers. Among mechanically ventilated patients, CF-carriers were more represented (8.7%) and they were significantly (p < 0.05) younger (mean age 51 years) compared to noncarriers (mean age 61.42 years). Furthermore, in the whole cohort, the age of male CF-carriers was lower, compared to noncarriers (p < 0.05). CF-carriers had a relative risk of presenting an abnormal inflammatory response (CRP >/= 20 mg/dL) of 1.69 (p < 0.05) and their hazard ratio of death at day 14 was 3.10 (p < 0.05) in a multivariate regression model, adjusted for age, sex and comorbidities. In conclusion, CF-carriers are more susceptible to the severe form of COVID-19, showing also higher risk of 14-day death. Twit Text FOAVip Severe COVID-19 in Hospitalized Carriers of Single CFTR Pathogenic Variants ????J Pers Med http://www.kidney.de/pget.php?&tw=1&pmid=34203982 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34203982 #FOAvip English Wikipedia <ref>{{Cite pmid|34203982}}</ref> Severe COVID-19 in Hospitalized Carriers of Single CFTR Pathogenic Variants #MMPMID34203982 Baldassarri M; Fava F; Fallerini C; Daga S; Benetti E; Zguro K; Amitrano S; Valentino F; Doddato G; Giliberti A; Di Sarno L; Palmieri M; Carriero ML; Alaverdian D; Beligni G; Iuso N; Castelli F; Quiros-Roldan E; Mondelli MU; Miceli R; Frullanti E; Furini S; Mari F; Renieri A; Gabbi C; On Behalf Of The Gen-Covid Multicenter Study J Pers Med 2021[Jun]; 11 (6): ä PMID34203982show ga The clinical presentation of COVID-19 is extremely heterogeneous, ranging from asymptomatic to severely ill patients. Thus, host genetic factors may be involved in determining disease presentation and progression. Given that carriers of single cystic fibrosis (CF)-causing variants of the CFTR gene-CF-carriers-are more susceptible to respiratory tract infections, our aim was to determine their likelihood of undergoing severe COVID-19. We implemented a cohort study of 874 individuals diagnosed with COVID-19, during the first pandemic wave in Italy. Whole exome sequencing was performed and validated CF-causing variants were identified. Forty subjects (16 females and 24 males) were found to be CF-carriers. Among mechanically ventilated patients, CF-carriers were more represented (8.7%) and they were significantly (p < 0.05) younger (mean age 51 years) compared to noncarriers (mean age 61.42 years). Furthermore, in the whole cohort, the age of male CF-carriers was lower, compared to noncarriers (p < 0.05). CF-carriers had a relative risk of presenting an abnormal inflammatory response (CRP >/= 20 mg/dL) of 1.69 (p < 0.05) and their hazard ratio of death at day 14 was 3.10 (p < 0.05) in a multivariate regression model, adjusted for age, sex and comorbidities. In conclusion, CF-carriers are more susceptible to the severe form of COVID-19, showing also higher risk of 14-day death. äSevere COVID-19 in Hospitalized Carriers of Single CFTR Pathogenic Var(epmc).pdf DeepDyve Pubget Overpricing