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10.3390/pathogens10060774

http://scihub22266oqcxt.onion/10.3390/pathogens10060774
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suck abstract from ncbi


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pmid34203060      Pathogens 2021 ; 10 (6): ä
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  • SARS-CoV-2 Seroprevalence and Neutralizing Antibody Response after the First and Second COVID-19 Pandemic Wave in Croatia #MMPMID34203060
  • Vilibic-Cavlek T; Stevanovic V; Ilic M; Barbic L; Capak K; Tabain I; Krleza JL; Ferenc T; Hruskar Z; Topic RZ; Kaliterna V; Antolovic-Pozgain A; Kucinar J; Koscak I; Mayer D; Sviben M; Antolasic L; Milasincic L; Bucic L; Ferencak I; Kaic B
  • Pathogens 2021[Jun]; 10 (6): ä PMID34203060show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus with a pandemic spread. So far, a total of 349,910 SARS-CoV-2 cases and 7687 deaths were reported in Croatia. We analyzed the seroprevalence and neutralizing (NT) antibody response in the Croatian general population after the first (May-July 2020) and second (December 2020-February 2021) pandemic wave. Initial serological testing was performed using a commercial ELISA, with confirmation of reactive samples by a virus neutralization test (VNT). A significant difference in the overall seroprevalence rate was found after the first (ELISA 2.2%, VNT 0.2%) and second waves (ELISA 25.1%, VNT 18.7%). Seropositive individuals were detected in all age groups, with significant differences according to age. The lowest prevalence of NT antibodies was documented in the youngest (<10 years; 16.1%) and the oldest (60-69/70+ years; 16.0% and 12.8%, respectively) age groups. However, these age groups showed the highest median NT titers (32-64). In other groups, seropositivity varied from 19.3% to 21.5%. A significant weak positive correlation between binding antibody level as detected by ELISA and VNT titer (rho = 0.439, p < 0.001) was observed. SARS-CoV-2 NT antibody titers seem to be age-related, with the highest NT activity in children under 10 years and individuals above 50 years.
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