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10.3390/pathogens10070805

http://scihub22266oqcxt.onion/10.3390/pathogens10070805
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34201967!8308615!34201967
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suck abstract from ncbi


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pmid34201967      Pathogens 2021 ; 10 (7): ä
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  • Study of the Plasma and Buffy Coat in Patients with SARS-CoV-2 Infection-A Preliminary Report #MMPMID34201967
  • Pena KB; Riu F; Guma J; Guilarte C; Pique B; Hernandez A; Avila A; Parra S; Castro A; Rovira C; Cueto P; Vallverdu I; Parada D
  • Pathogens 2021[Jun]; 10 (7): ä PMID34201967show ga
  • The pandemic caused by the SARS-CoV-2 infection affects many aspects of public health knowledge, science, and practice around the world. Several studies have shown that SARS-CoV-2 RNA in plasma seems to be associated with a worse prognosis of COVID-19. In the present study, we investigated plasma and buffy RNA in patients with COVID-19 to determine its prognostic value. A prospective study was carried out in patients hospitalized for COVID-19, in which RNA was analyzed in plasma and the buffy coat. Morphological and immunohistochemical studies were used to detect the presence of SARS-CoV-2 in the buffy coat. In COVID-19 patients, the obtained RNA concentration in plasma was 448.3 +/- 31.30 ng/mL. Of all the patients with positive plasma tests for SARS-CoV-2, 46.15% died from COVID-19. In four cases, tests revealed that SARS-CoV-2 was present in the buffy coat. Abnormal morphology of monocytes, lymphocytes and neutrophils was found. An immunohistochemical study showed positivity in mononuclear cells and platelets. Our results suggest that SARS-CoV-2 is present in the plasma. This facilitates viral dissemination and migration to specific organs, where SARS-CoV-2 infects target cells by binding to their receptors. In our study, the presence of plasma SARS-CoV-2 RNA was correlated with worse prognoses.
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