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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Vaccines+(Basel) 2021 ; 9 (6): ä Nephropedia Template TP
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A Unique SARS-CoV-2 Spike Protein P681H Variant Detected in Israel #MMPMID34201088
Zuckerman NS; Fleishon S; Bucris E; Bar-Ilan D; Linial M; Bar-Or I; Indenbaum V; Weil M; Lustig Y; Mendelson E; Mandelboim M; Mor O; Zuckerman N; On Behalf Of The Israel National Consortium For Sars-CoV-Sequencing
Vaccines (Basel) 2021[Jun]; 9 (6): ä PMID34201088show ga
The routine detection, surveillance, and reporting of novel SARS-CoV-2 variants is crucial, as these threaten to hinder global vaccination efforts. Herein we report a novel local variant with a non-synonymous mutation in the spike (S) protein P681H. This local Israeli variant was not associated with a higher infection rate or higher prevalence. Furthermore, the local variant was successfully neutralized by sera from fully vaccinated individuals at a comparable level to the B.1.1.7 variant and an Israel wild-type strain. While it is not a variant of concern, routine monitoring by sequencing is still required.