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Diagnostic Accuracy of a New Antigen Test for SARS-CoV-2 Detection #MMPMID34200827
Di Domenico M; De Rosa A; Di Gaudio F; Internicola P; Bettini C; Salzano N; Castrianni D; Marotta A; Boccellino M
Int J Environ Res Public Health 2021[Jun]; 18 (12): ä PMID34200827show ga
BACKGROUND AND AIMS: Quick and reliable diagnostic tools play an important role in controlling the spread of the SARS-Cov-2 pandemic. The aim of this study was to evaluate the diagnostic accuracy of a new cyto-salivary antigen test aimed at detecting the presence of antigens for SARS-CoV-2, as compared by the gold standard RT-PCR and a lateral flow test. METHODS: A total of 433 healthy volunteers were enrolled in the study and the sensitivity and specificity of the new cyto-salivary antigen test were calculated, as compared to the RT-PCR nasopharyngeal swab and to the lateral flow test. RESULTS: A total of 433 samples were collected and tested at the Mediterranean Fair in Palermo from February 2021 until April 2021. The new cyto-salivary antigen had a sensitivity of 100% and a specificity of 94.2%. The sensitivity and the specificity of the lateral flow test were 55% and 100%, respectively. CONCLUSIONS: The new cyto-salivary antigen test detected more positive cases than the RT-PCR in a sample of asymptomatic subjects, demonstrating to be a promising tool for a more sensitive diagnosis of COVID-19. Further studies are warranted to better characterize its diagnostic accuracy.
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Int+J+Environ+Res+Public+Health 2021 ; 18 (12): ä
